X0306 4 2019-03-14 0 0001404281 Novus Therapeutics, Inc. NVUS 0001664784 Kuwahara Jon C/O NOVUS THERAPEUTICS, INC. 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 0 1 0 0 See Remarks Stock Option (Right to Buy) 3.72 2019-03-14 4 A 0 25000 0.00 A 2029-03-14 Common Stock 25000 25000 D This option represents a right to purchase a total of 25,000 shares of the Issuer's Common Stock, which will vest in equal quarterly installments through the fourth anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer through each vesting date. Senior Vice President of Finance and Administration /s/ Ryan A. Murr, as attorney-in-fact for Jon Kuwahara 2019-03-18