X0206 3 2017-05-10 0 0001404281 Novus Therapeutics, Inc. NVUS 0001705287 FLESHER GREGORY J. C/O NOVUS THERAPEUTICS, INC 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 1 1 0 0 Chief Executive Officer Common Stock 56897 D Stock Option (Right to Buy) 19.76 2025-10-22 Common Stock 20301 D Stock Option (Right to Buy) 19.76 2026-12-15 Common Stock 4733 D All numbers give effect to the 1:9 reverse stock split effected by the Issuer on May 11, 2017. This option represents a right to purchase a total of 20,301 shares of the Issuer's Common Stock one quarter of which became fully vested and exercisable on July 30, 2016, with the remaining 15,225.75 shares vesting in equal quarterly installments over the following three years. This option represents a right to purchase a total of 4,733 shares of the Issuer's Common Stock one quarter of which became fully vested and exercisable on May 9, 2017, with the remaining 3,549.75 shares vesting in equal quarterly installments over the following three years. Exhibit List: Exhibit 24 - Power of Attorney. /s/ Ryan A. Murr, as attorney-in-fact for Gregory J. Flesher 2017-05-11