Shareholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands								3 Months Ended		6 Months Ended		120 Months Ended
	Jun. 30, 2022	Jun. 07, 2022	Jan. 31, 2022	Jan. 27, 2020	Jun. 24, 2019	Jun. 07, 2018	Jul. 14, 2006	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2028	Jun. 09, 2022	Jan. 05, 2022	Dec. 31, 2021	Mar. 31, 2018
Subsidiary or Equity Method Investee [Line Items]
Preferred stock, shares issued	0							0		0					0
Preferred stock, shares outstanding	0							0		0					0
Exercise price of warrants (in dollars per share)													$ 74.00
Class of warrant or right, number of securities called by each warrant or right													0.001
Individual penalty, threshold percentage										10.00%
Institutional investors penalty, threshold percentage										20.00%
Shares granted with respect to maximum fixed amount equal, percentage						20.00%	20.00%
Options granted under original plan exercisable period							10 years
Maximum number of common shares reserved for issuance						5,686,097
Shares issuable upon exercise of stock options																3,686,097
Number of shares available for grant	2,834,664							2,834,664		2,834,664					952,632
Proceeds from stock options exercised										$ 19
Expected average life of options										5 years 11 months 8 days	6 years 18 days
Unamortized compensation expense related to unvested options										$ 22,480
Remaining unamortized compensation expense, weighted-average period										1 year 7 months 28 days
Total amount contributed by ESPP participants	$ 739							$ 739		$ 739					$ 1,243
Forecast
Subsidiary or Equity Method Investee [Line Items]
Maximum number of common shares reserved for issuance increase in percentage												4.00%
Inducement Plan
Subsidiary or Equity Method Investee [Line Items]
Number of shares available for grant	250,000							250,000		250,000
Number of common shares reserved for issuance														750,000
Restricted Share Units (RSUs)
Subsidiary or Equity Method Investee [Line Items]
Shares available for issuance under the Original Plan exercisable period										3 years
Award vesting rights, percentage										33.00%
Nonvested award, cost not yet recognized, amount	$ 1,890							$ 1,890		$ 1,890
Nonvested award, cost not yet recognized, period for recognition	1 year 2 months 4 days
Compensation charge								477	$ 718	(126)	$ 1,324
Employees Stock Purchase Plan
Subsidiary or Equity Method Investee [Line Items]
Compensation charge								$ 107	$ 249	$ 290	$ 518
Maximum eligible employees contribution under ESPP	15.00%							15.00%		15.00%
Purchase of shares under ESPP, maximum limit for each employee										$ 25
Employee Stock
Subsidiary or Equity Method Investee [Line Items]
Percentage of discounted purchase price of average market price		85.00%
Share-based compensation arrangement by share-based payment award, stock plan offering period										6 months
Offering
Subsidiary or Equity Method Investee [Line Items]
Number of shares issued			11,035,000
Sale of stock (in dollars per share)			$ 8.00
Pre-funded warrants			3,340,000
Warrants issued price (in dollars per share)			$ 7.9999	$ 46.4999	$ 17.9999
Net proceeds from issuance			$ 107,534
Pre funded warrants issued in lieu of common shares to underwriters				1,075,271	4,166,690
Exercise price of warrants (in dollars per share)			$ 0.0001	$ 0.0001	$ 0.0001
Over-Allotment Option
Subsidiary or Equity Method Investee [Line Items]
Number of shares issued			1,875,000