Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 198,649	$ 201,867
Short-term investments (note 5)	43,184	50,741
Accounts receivable	4,196	15,614
Prepaid expenses and other current assets	17,037	19,998
Total current assets	263,066	288,220
Deferred financing fees	1,290	1,214
Long-term investments (note 5)	886	886
Long-term prepaid assets	16,078	12,490
Deferred tax asset	2,613	3,070
Property and equipment, net	26,157	22,783
Operating lease right-of-use assets	23,321	26,987
Intangible assets, net	5,913	3,838
Acquired in-process research and development (note 6)	17,628	17,628
Goodwill (note 6)	12,016	12,016
Total assets	368,968	389,132
Current liabilities:
Accounts payable and accrued liabilities (note 7)	76,685	62,767
Fair value of liability classified stock options	679	7,754
Current portion of operating lease liability (note 11)	2,725	1,310
Other current liabilities	0	22
Total current liabilities	80,089	71,853
Long-term portion of operating lease liability (note 11)	29,170	30,923
Deferred revenue (note 9)	32,941	32,941
Other long-term liabilities (note 7)	2,900	2,748
Deferred tax liability	1,586	1,573
Total liabilities	146,686	140,038
Shareholders’ equity:
Common shares, no par value; unlimited authorized shares at June 30, 2022 and December 31, 2021, respectively; 57,772,461 and 46,633,935 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively (note 8)	826,497	741,147
Additional paid-in capital	222,792	197,710
Accumulated other comprehensive loss	(6,659)	(6,659)
Accumulated deficit	(820,348)	(683,104)
Total shareholders’ equity	222,282	249,094
Total liabilities and shareholders’ equity	368,968	389,132
Commitments and contingencies (note 13)