Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 275,516	$ 201,867
Short-term investments (note 5)	25,018	50,741
Accounts receivable	4,228	15,614
Prepaid expenses and other current assets	19,260	19,998
Total current assets	324,022	288,220
Deferred financing fees	1,195	1,214
Long-term investments (note 5)	886	886
Long-term prepaid assets	17,532	12,490
Deferred tax asset	2,294	3,070
Property and equipment, net	25,747	22,783
Operating lease right-of-use assets	23,955	26,987
Intangible assets, net	4,702	3,838
Acquired in-process research and development (note 6)	17,628	17,628
Goodwill (note 6)	12,016	12,016
Total assets	429,977	389,132
Current liabilities:
Accounts payable and accrued liabilities (note 7)	76,334	62,767
Fair value of liability classified stock options (note 12)	2,488	7,754
Current portion of operating lease liability (note 11)	1,122	1,310
Other current liabilities	27	22
Total current liabilities	79,971	71,853
Long-term portion of operating lease liability (note 11)	30,599	30,923
Deferred revenue (note 9)	32,941	32,941
Other long-term liabilities (note 7)	2,490	2,748
Deferred tax liability	1,532	1,573
Total liabilities	147,533	140,038
Shareholders’ equity:
Common shares, no par value; unlimited authorized shares at March 31, 2022 and December 31, 2021, respectively; 57,770,246 and 46,633,935 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively (note 8)	826,459	741,147
Additional paid-in capital	218,373	197,710
Accumulated other comprehensive loss	(6,659)	(6,659)
Accumulated deficit	(755,729)	(683,104)
Total shareholders’ equity	282,444	249,094
Total liabilities and shareholders’ equity	429,977	389,132
Commitments and contingencies (note 13)