Shareholders' Equity - Schedule of Stock-based Compensation Expense for Equity Classified Instruments (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Research and development expenses	$ 199,752	$ 171,203	$ 117,367
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation charge	3,101	1,387	0
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation for equity classified instruments	20,090	12,299	5,939
Change in fair value of liability classified instruments	(4,646)	(6)	8,358
Research and development expenses	15,444	12,293	14,297
General and Administrative Expenses
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation for equity classified instruments	18,184	14,645	6,737
Change in fair value of liability classified instruments	(23,758)	1,416	27,470
General and administrative expenses	(5,574)	16,061	34,207
Finance Expense (Income)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation for equity classified instruments	0	0	0
Change in fair value of liability classified instruments	(129)	(41)	166
Finance expenses	$ (129)	$ (41)	$ 166