Shareholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands						12 Months Ended			120 Months Ended
	Jan. 31, 2022	Jan. 27, 2020	Jun. 24, 2019	Jun. 07, 2018	Jul. 14, 2006	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2028	Jan. 05, 2022	Mar. 31, 2018
Temporary Equity [Line Items]
Preferred stock, shares issued						0	0
Preferred stock, shares outstanding						0	0
Warrant exercise price			$ 0.0001
Shares granted with respect to maximum fixed amount equal, percentage				20.00%
Maximum number of common shares reserved for issuance				5,686,097
Shares issuable upon exercise of stock options											3,686,097
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant						952,632	1,242,038
Proceeds from stock options exercised						$ 6,428	$ 7,111	$ 5,498
Stock-based compensation						38,275	26,945	12,676
Derivative liability, classified stock options and ESPP						$ (27,517)	$ 2,171	$ 36,320
Expected average life of options						6 years 18 days	6 years 14 days	6 years 10 days
Option exercised intrinsic value						$ 10,998	$ 19,446	$ 9,416
Unamortized compensation expense related to unvested options						$ 33,960
Remaining unamortized compensation expense, weighted-average period						1 year 10 months 24 days
Maximum
Temporary Equity [Line Items]
Expected average life of options						10 years
Forecast
Temporary Equity [Line Items]
Maximum number of common shares reserved for issuance increase in percentage									4.00%
Offering
Temporary Equity [Line Items]
Number of common shares issued		5,824,729	7,013,892
Share issued price per share (in dollars per share)		$ 46.50	$ 18.00
Warrants issued price per pre funded warrant (in dollars per share)		$ 46.4999	$ 17.9999
Net proceeds from issuance		$ 300,910	$ 188,005
Payments of stock issuance costs		$ 19,940	$ 13,245
Warrant exercise price		$ 0.0001
Offering | Subsequent Event
Temporary Equity [Line Items]
Class of warrant or right, pre-funded (in shares)	3,340,000
Warrants issued price per pre funded warrant (in dollars per share)	$ 7.9999
Net proceeds from issuance	$ 107,600
Over-Allotment Option
Temporary Equity [Line Items]
Number of shares issued to underwriters		900,000	1,458,336
Class of warrant or right, pre-funded (in shares)		1,075,271	4,166,690
Original Stock Option Plan
Temporary Equity [Line Items]
Shares granted with respect to maximum fixed amount equal, percentage					20.00%
Share-based compensation arrangement by share-based payment award, expiration period						10 years
Inducement Plan | Subsequent Event
Temporary Equity [Line Items]
Common stock, capital shares reserved for future issuance										750,000
Restricted Stock Units (RSUs)
Temporary Equity [Line Items]
Shares available for issuance, vesting period							3 years
Nonvested award, cost not yet recognized, amount						$ 5,224
Nonvested award, cost not yet recognized, period for recognition						1 year 5 months 19 days
Compensation charge						$ 3,101	$ 1,387	$ 0
Employees Stock Purchase Plan
Temporary Equity [Line Items]
Compensation charge						$ 1,016	803
Maximum eligible employees contribution under ESPP						15.00%
Purchase of shares under ESPP, maximum limit for each employee						$ 25
Total amount contributed by ESPP participants						$ 1,243	$ 926