Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 201,867	$ 242,036
Short-term investments (note 5)	50,741	184,318
Accounts receivable	15,614	15,293
Prepaid expenses and other current assets	19,998	13,429
Total current assets	288,220	455,076
Deferred financing fees	1,214	805
Long-term investments (note 5)	886	25,921
Long-term prepaid assets	12,490	2,290
Deferred tax asset (note 14)	3,070	1,723
Property and equipment, net (note 7)	22,783	12,185
Operating lease right-of-use assets (note 15)	26,987	5,429
Intangible assets, net (note 8)	3,838	5,303
Acquired in-process research and development (note 6)	17,628	17,628
Goodwill (note 6)	12,016	12,016
Total assets	389,132	538,376
Current liabilities:
Accounts payable and accrued liabilities (note 9)	62,767	43,655
Fair value of liability-classified stock options	7,754	39,284
Current portion of operating lease liability (note 15)	1,310	2,710
Other current liabilities	22	17
Total current liabilities	71,853	85,666
Long-term portion of operating lease liability (note 15)	30,923	5,812
Deferred revenue (note 12)	32,941	32,941
Other long-term liabilities (note 9)	2,748	2,857
Deferred tax liability (note 14)	1,573	1,178
Total liabilities	140,038	128,454
Shareholders’ equity:
Common shares, no par value; unlimited authorized shares at December 31, 2021 and 2020; 46,633,935 and 46,035,389 shares issued and outstanding at December 31, 2021 and 2020, respectively (note 10b)	741,147	724,219
Additional paid-in capital	197,710	163,623
Accumulated other comprehensive loss	(6,659)	(6,659)
Accumulated deficit	(683,104)	(471,261)
Total shareholders’ equity	249,094	409,922
Total liabilities and shareholders’ equity	389,132	538,376
Commitments and contingencies (note 17)