Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 279,947	$ 242,036
Short-term investments (note 5)	131,527	184,318
Accounts receivable	4,576	15,293
Prepaid expenses and other current assets	16,718	13,429
Total current assets	432,768	455,076
Deferred financing fees	848	805
Long-term investments (note 5)	886	25,921
Long-term prepaid assets	2,149	2,290
Deferred tax asset	1,813	1,723
Property and equipment, net	12,305	12,185
Operating lease right-of-use assets	5,433	5,429
Intangible assets, net	4,213	5,303
Acquired in-process research and development (note 6)	17,628	17,628
Goodwill (note 6)	12,016	12,016
Total assets	490,059	538,376
Current liabilities:
Accounts payable and accrued liabilities (note 7)	43,654	43,655
Fair value of liability classified stock options (note 12)	23,617	39,284
Current portion of operating lease liability (note 11)	2,952	2,710
Other current liabilities	22	17
Total current liabilities	70,245	85,666
Long-term portion of operating lease liability (note 11)	5,333	5,812
Deferred revenue (note 9)	32,941	32,941
Other long-term liabilities (note 7)	2,880	2,857
Deferred tax liability	1,515	1,178
Total liabilities	112,914	128,454
Shareholders’ equity:
Common shares, no par value; unlimited authorized shares at March 31, 2021 and December 31, 2020, respectively; 46,164,888 and 46,035,389 shares issued and outstanding at March 31, 2021 and December 31, 2020, respectively (note 8b)	729,007	724,219
Additional paid-in capital	170,648	163,623
Accumulated other comprehensive loss	(6,659)	(6,659)
Accumulated deficit	(515,851)	(471,261)
Total shareholders’ equity	377,145	409,922
Total liabilities and shareholders’ equity	490,059	538,376
Commitments and contingencies (note 13)