Shareholders' Equity - Schedule of Stock-based Compensation Expense for Equity Classified Instruments (Detail) - USD ($)	3 Months Ended
Mar. 31, 2020	Mar. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Research and development expenses	$ 36,526,000	$ 17,475,000
General and administrative expenses	7,623,000	9,003,000
Restricted Share Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation charge	91,000	0
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation for equity classified instruments	2,016,000	1,127,000
Change in fair value of liability classified equity instruments	(1,794,000)	420,000
Research and development expenses	222,000	1,547,000
General and Administrative Expenses
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation for equity classified instruments	2,228,000	1,490,000
Change in fair value of liability classified equity instruments	(5,379,000)	1,326,000
General and administrative expenses	(3,151,000)	2,816,000
Finance Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Change in fair value of liability classified equity instruments	(34,000)	15,000
Finance expenses	$ (34,000)	$ 15,000

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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