<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0707</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001403752</cik>
        <entityName>Zymeworks Inc.</entityName>
        <issuerAddress>
            <street1>540-1385 WEST 8TH AVENUE</street1>
            <city>VANCOUVER</city>
            <stateOrCountry>A1</stateOrCountry>
            <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
            <zipCode>V6H 3V9</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(604) 678-1388</issuerPhoneNumber>
        <jurisdictionOfInc>BRITISH COLUMBIA, CANADA</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Zymeworks Inc</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

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            <relatedPersonName>
                <firstName>ALI</firstName>
                <lastName>TEHRANI</lastName>
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            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>NEIL</firstName>
                <lastName>KLOMPAS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
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                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>SURJIT</firstName>
                <lastName>DIXIT</lastName>
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                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
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                <zipCode>V6H 3V9</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <lastName>TUCKER</lastName>
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                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
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                <zipCode>V6H 3V9</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>KENNETH</firstName>
                <lastName>GALBRAITH</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>NOEL</firstName>
                <lastName>HALL</lastName>
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            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
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                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SHERMAINE</firstName>
                <lastName>TILLEY</lastName>
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            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
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                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DONALD</firstName>
                <lastName>DRAKEMAN</lastName>
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                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
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                <zipCode>V6H 3V9</zipCode>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DION</firstName>
                <lastName>MADSEN</lastName>
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                <street1>C/O ZYMEWORKS INC.</street1>
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                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>NICK</firstName>
                <lastName>BEDFORD</lastName>
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            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GORDON</firstName>
                <lastName>NG</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>AMOS</firstName>
                <lastName>MICHELSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O ZYMEWORKS INC.</street1>
                <street2>540-1385 WEST 8TH AVENUE</street2>
                <city>VANCOUVER</city>
                <stateOrCountry>A1</stateOrCountry>
                <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                <zipCode>V6H 3V9</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2016-01-07</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>BMO CAPITAL MARKETS CORP.</recipientName>
                <recipientCRDNumber>16686</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>3 TIMES SQUARE</street1>
                    <street2>27TH FLOOR</street2>
                    <city>NEW YORK</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10036</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>MTS SECURITIES LLC</recipientName>
                <recipientCRDNumber>104059</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>623 FIFTH AVENUE</street1>
                    <street2>14TH FLOOR</street2>
                    <city>NEW YORK</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>75000003</totalOfferingAmount>
            <totalAmountSold>61517859</totalAmountSold>
            <totalRemaining>13482144</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>15</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>2100002</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Zymeworks Inc.</issuerName>
                <signatureName>/S/ NEIL KLOMPAS</signatureName>
                <nameOfSigner>NEIL KLOMPAS</nameOfSigner>
                <signatureTitle>CHIEF FINANCIAL OFFICER</signatureTitle>
                <signatureDate>2016-01-21</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
