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        <entityName>Zymeworks Inc.</entityName>
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            <city>Vancouver</city>
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            <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
            <zipCode>V6H 3V9</zipCode>
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        <jurisdictionOfInc>BRITISH COLUMBIA, CANADA</jurisdictionOfInc>
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                <relationship>Director</relationship>
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            <relatedPersonName>
                <firstName>NEIL</firstName>
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                <firstName>DAVID</firstName>
                <lastName>TUCKER</lastName>
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                <firstName>NOEL</firstName>
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                <firstName>DONALD</firstName>
                <lastName>DRAKEMAN</lastName>
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                <firstName>HAIG</firstName>
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                <firstName>NICK</firstName>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GORDON</firstName>
                <lastName>NG</lastName>
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                <street2>540-1385 WEST 8TH AVENUE</street2>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>AMOS</firstName>
                <lastName>MICHELSON</lastName>
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                <street2>540-1385 WEST 8TH AVENUE</street2>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001403752-14-000003</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2014-10-22</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
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        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>23988700</totalOfferingAmount>
            <totalAmountSold>23988700</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Securities were offered &amp; sold in Canadian dollars, with a Total Offering Amount of CAD$27,000,000 &amp; Total Amount Sold of CAD$27,000,000.  The amounts in the lines above reflect the US dollar amounts based on the exchange rate on the Date of First Sale.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
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        <useOfProceeds>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Zymeworks Inc.</issuerName>
                <signatureName>/S/ NEIL KLOMPAS</signatureName>
                <nameOfSigner>NEIL KLOMPAS</nameOfSigner>
                <signatureTitle>CHIEF FINANCIAL OFFICER</signatureTitle>
                <signatureDate>2015-01-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
