X0206 3 2022-02-24 0 0001403752 Zymeworks Inc. ZYME 0001915257 Astle Christopher C/O ZYMEWORKS INC. 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER A1 V5T 1G4 BRITISH COLUMBIA, CANADA 0 1 0 0 SVP & Chief Financial Officer Common Shares 670 D Stock Option (Right to Buy) 29.8055 2031-05-16 Common Shares 17250 D Restricted Stock Unit Common Shares 3100 D Stock options vest as follows: (i) 25% on May 17, 2022 (the first anniversary of grant date) and (ii) remainder in 36 equal monthly installments on last day of each month following first anniversary of grant date. The exercise price of the stock option was converted from CAD36.01 using the closing rate of exchange of the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. The restricted stock units vest in two equal annual installments beginning on December 10, 2022. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Exhibit List - Exhibit 24 - Power of Attorney /s/ Daniel Dex, Attorney-in-Fact 2022-03-04