X0306 4 2022-01-07 0 0001403752 Zymeworks Inc. ZYME 0001864141 Josephson Neil C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Medical Officer Common Shares 2022-01-07 4 A 0 65 13.94 A 2119 D Shares purchased pursuant to the Issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period July 1, 2021 through December 31, 2021. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the Issuer's common shares on December 31, 2021. /s/ Daniel Dex, Attorney-in-Fact 2022-01-07