X0306 4 2021-07-06 0 0001403752 Zymeworks Inc. ZYME 0001791978 O'Driscoll Kathryn C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief People Officer Common Shares 2021-07-06 4 A 0 510 29.49 A 6350 D Shares purchased pursuant to the Issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period January 1, 2021 through June 30, 2021. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the Issuer's common shares on June 30, 2021. /s/ Daniel Dex, Attorney-in-Fact 2021-07-08