X0306 4 2020-12-01 0 0001403752 Zymeworks Inc. ZYME 0001563992 HAUSMAN DIANA C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Medical Officer Common Shares 2020-12-01 4 M 0 4122 9.82 A 7840 D Common Shares 2020-12-01 4 M 0 14145 11.84 A 21985 D Common Shares 2020-12-01 4 S 0 18267 55.1946 D 3718 D Common Shares 2020-12-02 4 M 0 127 9.82 A 3845 D Common Shares 2020-12-02 4 M 0 574 11.84 A 4419 D Common Shares 2020-12-02 4 S 0 701 55.0114 D 3718 D Common Shares 2000 I Held by spouse Stock Option (Right to Buy) 9.82 2020-12-01 4 M 0 4122 0.00 D 2018-06-12 2027-06-12 Common Shares 4122 70878 D Stock Option (Right to Buy) 11.84 2020-12-01 4 M 0 14145 0.00 D 2019-03-19 2028-03-18 Common Shares 14145 50855 D Stock Option (Right to Buy) 9.82 2020-12-02 4 M 0 127 0.00 D 2018-06-12 2027-06-12 Common Shares 127 70751 D Stock Option (Right to Buy) 11.84 2020-12-02 4 M 0 574 0.00 D 2019-03-19 2028-03-18 Common Shares 574 50281 D Pursuant to a 10b5-1 plan. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.00 to $55.67, inclusive. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 1, 2020 at each separate price. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.00 to $55.05, inclusive. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 2, 2020 at each separate price. Stock options vest as follows: (i) 25% of underlying shares on first anniversary of grant date and (ii) remainder of underlying shares in 36 equal monthly installments on last day of month following the first anniversary of grant date. The grant date was ten years before the listed expiration date. /s/ Daniel Dex, Attorney-in-Fact 2020-12-03