X0306 4 2020-01-08 0 0001403752 Zymeworks Inc. ZYME 0001729957 Polverino Anthony J. C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Scientific Officer Common Shares 2020-01-08 4 A 0 371 19.54 A 28991 D Shares purchased pursuant to the issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period July 1, 2019 through December 31, 2019. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the issuer's common shares on July 1, 2019. /s/ Daniel Dex, Attorney-in-Fact 2020-01-08