X0306 4 2019-07-08 0 0001403752 Zymeworks Inc. ZYME 0001761857 Klompas Neil A C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Financial Officer Common Shares 2019-07-08 4 A 0 464 12.49 A 8441 D Common Shares 700 I Held by spouse Shares purchased pursuant to the issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period January 1, 2019 through June 30, 2019. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the issuer's common shares on January 2, 2019. /s/ Daniel Dex, Attorney-in-Fact 2019-07-10