X0306 4 2019-01-08 0 0001403752 Zymeworks Inc. ZYME 0001761857 Klompas Neil A C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Financial Officer Common Shares 2019-01-08 4 A 0 414 12.48 A 1201 D Stock Option (Right to Buy) 15.53 2019-01-08 4 A 0 90000 0.00 A 2029-01-07 Common Shares 90000 90000 D Shares purchased pursuant to the issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period July 1, 2018 through December 31, 2018. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the issuer's common shares on December 31, 2018. Stock options vest as follows: (i) 25% of underlying shares on first anniversary of grant date and (ii) remainder of underlying shares in 36 equal monthly installments on last day of month following first anniversary of grant date. /s/ Daniel Dex, Attorney-in-Fact 2019-01-10