Statements of Stockholders' Equity - USD ($)	Total	At-The-Market Offering [Member]	Common Stock [Member]	Common Stock [Member] At-The-Market Offering [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] At-The-Market Offering [Member]	Accumulated Deficit [Member]
Beginning Balance at Dec. 31, 2015	$ 3,464,929		$ 720		$ 51,524,821		$ (48,060,612)
Beginning Balance, Shares at Dec. 31, 2015			7,201,774
Stock-based compensation expense	1,706,524				1,706,524
Issuance of common stock, net		$ 256,113		$ 6		$ 256,107
Issuance of common stock, shares net				56,000
Issuance of common stock from employee stock purchase plan	$ 98,742		$ 3		98,739
Issuance of common stock from employee stock purchase plan, Shares	34,067		34,067
Issuance of common stock from warrant exercise			$ 1		(1)
Issuance of common stock from warrant exercise, Shares			9,887
Issuance of common stock and warrants, net	$ 8,803,036		$ 505		8,802,531
Issuance of common stock and warrants, shares net			5,048,632
Reclassification of warrant liability due to warrant amendment and exercise	206,825				206,825
Net loss	(10,748,531)						(10,748,531)
Ending Balance at Dec. 31, 2016	$ 3,787,638		$ 1,235		62,595,546		(58,809,143)
Ending Balance, Shares at Dec. 31, 2016	12,350,360		12,350,360
Stock-based compensation expense	$ 1,819,431				1,819,431
Issuance of common stock, net	7,254,348		$ 278		7,254,070
Issuance of common stock, shares net			2,775,861
Issuance of common stock from employee stock purchase plan	$ 134,753		$ 7		134,746
Issuance of common stock from employee stock purchase plan, Shares	75,529		75,529
Issuance of common stock from warrant exercise			$ 21		(21)
Issuance of common stock from warrant exercise, Shares			211,860
Reclassification of warrant liability due to warrant amendment and exercise	$ 1,399,091				1,399,091
Net loss	(12,229,512)						(12,229,512)
Ending Balance at Dec. 31, 2017	$ 2,165,749		$ 1,541		$ 73,202,863		$ (71,038,655)
Ending Balance, Shares at Dec. 31, 2017	15,413,610		15,413,610