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Preferred Stock, Common Stock and Stockholders' Equity - Summary of Estimated Fair Value of Stock Option Award (Detail) - Common stock options [Member]
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Stock-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk free interest rate, minimum 1.93% 1.25%
Risk free interest rate, maximum 2.16% 1.58%
Expected volatility of common stock, minimum 94.05% 74.44%
Expected volatility of common stock, maximum 98.23% 75.91%
Expected dividend yield 0.00% 0.00%
Minimum [Member]    
Stock-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected option term 5 years 6 months 5 years 3 months 18 days
Maximum [Member]    
Stock-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected option term 6 years 6 years