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Debt - Additional Information (Detail) - Square 1 Bank [Member] - USD ($)
1 Months Ended 3 Months Ended
Oct. 05, 2015
Sep. 30, 2015
May. 31, 2014
Mar. 31, 2016
Dec. 31, 2014
Debt Instrument [Line Items]          
Patient enrollment covenant   75.00%      
Maximum [Member]          
Debt Instrument [Line Items]          
Cash burn under credit facility       4.00%  
Maximum [Member] | Upon Receive Positive Results From Phase 3 Trial [Member]          
Debt Instrument [Line Items]          
Cash burn under credit facility       3.00%  
Minimum [Member]          
Debt Instrument [Line Items]          
Cash burn under credit facility       1.00%  
Minimum [Member] | Upon Receive Positive Results From Phase 3 Trial [Member]          
Debt Instrument [Line Items]          
Cash burn under credit facility       1.00%  
Loan and security agreement [Member]          
Debt Instrument [Line Items]          
Loan and security agreement, available credit     $ 4,500,000    
Loan and security agreement, amount drawn         $ 4,500,000
Fixed interest rate         5.50%
Debt instrument interest payment, extended date Nov. 28, 2016        
Credit facility maturity date       Nov. 28, 2018  
Loan and security agreement, amount of other indebtedness     400,000 $ 400,000  
Warrants exercisable, stock issued       22,881  
Warrant exercise price per share       $ 5.90  
Warrant expiration date       Dec. 31, 2024  
Line of credit facility, loan origination cost     $ 82,685    
Loan and security agreement [Member] | Warrant [Member]          
Debt Instrument [Line Items]          
Debt Instrument, Unamortized Discount       $ 108,122  
Warrant value recorded in equity       $ 108,122