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Debt - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Oct. 05, 2015
May. 28, 2014
May. 23, 2014
Sep. 30, 2015
Jun. 30, 2012
Dec. 31, 2015
Dec. 31, 2014
Jan. 31, 2013
Debt Instrument [Line Items]                
Repayment of principal and accrued interest             $ 3,000,000  
Debt Instrument, Unamortized Discount [1]           $ 73,978    
Warrant exercise price per share           $ 16.73 $ 16.73  
Line of credit facility, loan origination cost             $ 82,685  
Loan and security agreement [Member]                
Debt Instrument [Line Items]                
Loan and security agreement, interest incurred           $ 250,938 47,165  
Silicon Valley Bank [Member] | Loan and security agreement [Member]                
Debt Instrument [Line Items]                
Loan and security agreement, maximum credit         $ 3,000,000      
Loan and security agreement, amount drawn               $ 3,000,000
Loan and security agreement, interest rate         4.50%      
Loan and security agreement, payback period         24 months      
Repayment of principal and accrued interest     $ 2,400,000          
Debt Instrument, Unamortized Discount     $ 38,000          
Square 1 Bank [Member]                
Debt Instrument [Line Items]                
Patient enrollment covenant       75.00%        
Square 1 Bank [Member] | Maximum [Member]                
Debt Instrument [Line Items]                
Cash burn under credit facility           4.00%    
Square 1 Bank [Member] | Maximum [Member] | Upon Receive Positive Results From Phase 3 Trial [Member]                
Debt Instrument [Line Items]                
Cash burn under credit facility           3.00%    
Square 1 Bank [Member] | Minimum [Member]                
Debt Instrument [Line Items]                
Cash burn under credit facility           1.00%    
Square 1 Bank [Member] | Minimum [Member] | Upon Receive Positive Results From Phase 3 Trial [Member]                
Debt Instrument [Line Items]                
Cash burn under credit facility           1.00%    
Square 1 Bank [Member] | Loan and security agreement [Member]                
Debt Instrument [Line Items]                
Loan and security agreement, amount drawn           $ 4,500,000 $ 4,500,000  
Loan and security agreement, available credit   $ 4,500,000            
Fixed interest rate             5.50%  
Debt instrument interest payment, extended date Nov. 28, 2016              
Credit facility maturity date           Nov. 28, 2018    
Loan and security agreement, amount of other indebtedness   400,000       $ 400,000    
Warrants exercisable, stock issued           22,881    
Warrant exercise price per share           $ 5.90    
Warrant expiration date           Dec. 31, 2024    
Line of credit facility, loan origination cost   $ 82,685            
Square 1 Bank [Member] | Loan and security agreement [Member] | Warrant [Member]                
Debt Instrument [Line Items]                
Debt Instrument, Unamortized Discount           $ 108,122    
Warrant value recorded in equity           $ 108,122    
[1] Represents the initial fair value of the detachable warrants to purchase common stock issued in connection with the term debt, net of amortization.