X0303 4 2010-12-22 0 0000716646 CLINICAL DATA INC CLDA 0001403477 Reed Carol C/O CLINICAL DATA, INC. ONE GATEWAY CENTER, SUITE 702 NEWTON MA 02458 0 1 0 0 EVP and Chief Medical Officer Stock Option (Right to Buy) 16.54 2010-12-22 4 A 0 85000 0.00 A 2020-12-22 Common Stock 85000 85000 D Exercisable as to 28,334 shares on December 22, 2011, as to an additonal 28,333 shares on December 22, 2012, and as to an additional 28,333 shares on December 22, 2013. Such options shall become immediately exercisable, among other events, upon a change of control of the issuer. /s/ Carol Reed 2010-12-23