X0206 3 2015-06-26 0 0001401914 Cerulean Pharma Inc. CERU 0001307183 ONeill James E C/O CERULEAN PHARMA INC. 35 GATEHOUSE DRIVE WALTHAM MA 02451 0 1 0 0 Principal Accounting Officer Common Stock 1000 D Incentive Stock Option (right to buy) 4.40 2024-10-07 Common Stock 13000 D Incentive Stock Option (right to buy) 8.16 2025-02-04 Common Stock 4900 D This option was granted on October 8, 2014 and is scheduled to vest over four years, with 25% of the shares vesting on the first anniversary of September 15, 2014 and the remainder vesting over the ensuing three years at a rate of 2.0833% per month. This option was granted on February 5, 2015. The shares underlying the option are scheduled to vest in equal monthly installments from January 31, 2015 through December 31, 2018. /s/ Alejandra Carvajal, as attorney-in-fact for James E. O'Neill 2016-05-27