Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Additional Paid-in Capital	Additional Paid-in Capital Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
Balance at (in shares) at Dec. 31, 2019			36,298,000
Balances at at Dec. 31, 2019	$ 104,151,000		$ 4,000	$ 535,954,000		$ 145,000	$ (431,952,000)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock net of issuance costs (in shares)			5,750,000
Issuance of common stock net of issuance costs	215,765,000			215,765,000
Exercise of stock options (in shares)			1,890,000
Issuance of common stock for employee stock purchase plan (in shares)			89,000
Exercise of common stock warrant, net (in shares)			414,000
Net loss	(110,078,000)						(110,078,000)
Balance at (in shares) at Dec. 31, 2020			44,441,000
Balances at at Dec. 31, 2020	306,948,000	$ (51,012,000)	$ 4,000	848,891,000	$ (58,543,000)	83,000	(542,030,000)	$ 7,531,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock for employee stock purchase plan (in shares)			65,000
Net loss	(115,254,000)						(115,254,000)
Balance at (in shares) at Dec. 31, 2021			45,729,000
Balances at at Dec. 31, 2021	$ 176,962,000		$ 5,000	827,028,000		(318,000)	(649,753,000)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options (in shares)	128,627
Issuance of common stock for employee stock purchase plan (in shares)			150,000
Net loss	$ (159,543,000)						(159,543,000)
Balance at (in shares) at Dec. 31, 2022			46,719,000
Balances at at Dec. 31, 2022	$ 45,814,000		$ 5,000	$ 855,694,000		$ (589,000)	$ (809,296,000)