Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenue:
Revenue	$ 29,541	$ 37,150	$ 92,840	$ 102,630
Costs and expenses:
Cost of product revenue	13,723	17,154	44,353	48,258
Research and development	16,992	19,117	51,755	51,342
Selling, general and administrative	33,767	30,253	106,234	83,907
Total costs and expenses	64,482	66,524	202,342	183,507
Loss from operations	(34,941)	(29,374)	(109,502)	(80,877)
Other income (expense):
Interest income	774	153	1,331	502
Interest expense	(1,887)	(1,876)	(5,650)	(5,614)
Other income (expense), net	(579)	(223)	(1,286)	79
Total other expense, net	(1,692)	(1,946)	(5,605)	(5,033)
Net loss before provision for income tax	(36,633)	(31,320)	(115,107)	(85,910)
Provision for income tax	(57)	59	(322)	(83)
Net loss	$ (36,690)	$ (31,261)	$ (115,429)	$ (85,993)
Net loss per share - basic (in dollars per share)	$ (0.79)	$ (0.69)	$ (2.49)	$ (1.90)
Net loss per share - diluted (in dollars per share)	$ (0.79)	$ (0.69)	$ (2.49)	$ (1.90)
Weighted average shares used in computing basic net loss per share (in shares)	46,529	45,558	46,320	45,170
Weighted average shares used in computing diluted net loss per share (in shares)	46,529	45,558	46,320	45,170
Total product and service revenue
Revenue:
Revenue	$ 29,466	$ 36,924	$ 92,305	$ 101,950
Product
Revenue:
Revenue	24,605	32,523	78,561	90,028
Costs and expenses:
Cost of product revenue	10,159	13,286	33,592	37,090
Service revenue
Revenue:
Revenue	4,861	4,401	13,744	11,922
Costs and expenses:
Cost of product revenue	3,564	3,868	10,761	11,168
Collaboration revenue
Revenue:
Revenue	$ 75	$ 226	$ 535	$ 680