Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Revenue	$ 32,219	$ 33,863	$ 63,299	$ 65,480
Costs and expenses:
Cost of product revenue	15,852	15,481	30,630	31,104
Research and development	17,346	17,162	34,763	32,225
Selling, general and administrative	36,112	26,855	72,467	53,654
Total costs and expenses	69,310	59,498	137,860	116,983
Loss from operations	(37,091)	(25,635)	(74,561)	(51,503)
Other income (expense):
Interest income	406	231	557	349
Interest expense	(1,880)	(1,868)	(3,763)	(3,738)
Other income (expense), net	(490)	334	(707)	302
Total other expense, net	(1,964)	(1,303)	(3,913)	(3,087)
Net loss before provision for income tax	(39,055)	(26,938)	(78,474)	(54,590)
Provision for income tax	(184)	(82)	(265)	(142)
Net loss	$ (39,239)	$ (27,020)	$ (78,739)	$ (54,732)
Net loss per share - basic (in dollars per share)	$ (0.85)	$ (0.60)	$ (1.70)	$ (1.22)
Net loss per share - diluted (in dollars per share)	$ (0.85)	$ (0.60)	$ (1.70)	$ (1.22)
Weighted average shares used in computing basic net loss per share (in shares)	46,427	45,274	46,201	44,973
Weighted average shares used in computing diluted net loss per share (in shares)	46,427	45,274	46,201	44,973
Total product and service revenue
Revenue:
Revenue	$ 31,998	$ 33,632	$ 62,839	$ 65,026
Product
Revenue:
Revenue	27,385	29,797	53,956	57,505
Costs and expenses:
Cost of product revenue	11,961	11,758	23,433	23,804
Service revenue
Revenue:
Revenue	4,613	3,835	8,883	7,521
Costs and expenses:
Cost of product revenue	3,891	3,723	7,197	7,300
Collaboration revenue
Revenue:
Revenue	$ 221	$ 231	$ 460	$ 454