Consolidated Statements of Operations - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue	$ 145,085,000	$ 117,316,000	$ 125,568,000
Cost of product revenue	68,304,000	52,409,000	44,039,000
Revenue:
Revenue	145,085,000	117,316,000	125,568,000
Total revenue	145,085,000	117,316,000	125,568,000
Costs and expenses:
Cost of product revenue	68,304,000	52,409,000	44,039,000
Research and development	69,504,000	62,857,000	68,035,000
Selling, general and administrative	115,503,000	90,097,000	96,195,000
Total costs and expenses	253,311,000	205,363,000	208,269,000
Loss from operations	(108,226,000)	(88,047,000)	(82,701,000)
Other income (expense):
Gain on sale of business, net	0	0	48,871,000
Loss on extinguishment of debt and termination of revolving loan facility	0	(7,143,000)	0
Interest income	649,000	1,744,000	2,819,000
Interest expense	(7,490,000)	(15,408,000)	(8,487,000)
Other expense, net	(20,000)	(971,000)	(929,000)
Total other income (expense), net	(6,861,000)	(21,778,000)	42,274,000
Net loss before provision for income taxes	(115,087,000)	(109,825,000)	(40,427,000)
Provision for income taxes	(167,000)	(253,000)	(269,000)
Net loss	$ (115,254,000)	$ (110,078,000)	$ (40,696,000)
Net loss per share-basic and diluted (in dollars per share)	$ (2.54)	$ (2.82)	$ (1.18)
Weighted average shares used in computing basic and diluted net loss per share (in shares)	45,299	39,083	34,588
Service revenue
Revenue	$ 16,495,000	$ 13,517,000	$ 11,636,000
Cost of product revenue	14,636,000	7,408,000	6,224,000
Revenue:
Revenue	16,495,000	13,517,000	11,636,000
Costs and expenses:
Cost of product revenue	14,636,000	7,408,000	6,224,000
Total product revenue
Revenue	127,462,000	97,927,000	92,078,000
Cost of product revenue	53,668,000	45,001,000	37,815,000
Revenue:
Revenue	127,462,000	97,927,000	92,078,000
Costs and expenses:
Cost of product revenue	53,668,000	45,001,000	37,815,000
Collaboration
Revenue	1,128,000	5,872,000	21,854,000
Revenue:
Revenue	$ 1,128,000	$ 5,872,000	$ 21,854,000