Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Revenue:
Revenue	$ 31,845	$ 30,604	$ 81,054	$ 88,637
Costs and expenses:
Cost of product and service revenue	13,962	10,925	35,691	29,239
Research and development	14,993	17,007	48,234	50,063
Selling, general and administrative	20,474	23,382	66,107	69,317
Total costs and expenses	49,429	51,314	150,032	148,619
Loss from operations	(17,584)	(20,710)	(68,978)	(59,982)
Other income (expense):
Interest income	333	763	1,516	2,114
Interest expense	(4,154)	(2,415)	(11,153)	(6,052)
Other income (expense), net	159	(322)	(1,116)	(552)
Loss on extinguishment of debt and termination of revolving loan facility	0	0	(7,143)	0
Total other expense, net	(3,662)	(1,974)	(17,896)	(4,490)
Net loss before provision for income tax	(21,246)	(22,684)	(86,874)	(64,472)
Provision for income tax	(71)	(64)	(200)	(211)
Net loss	$ (21,317)	$ (22,748)	$ (87,074)	$ (64,683)
Net loss per share - basic and diluted (in dollars per share)	$ (0.56)	$ (0.64)	$ (2.31)	$ (1.90)
Weighted average shares used in computing basic and diluted net loss per share (in shares)	38,081	35,576	37,624	34,121
Total product and service revenue
Revenue:
Revenue	$ 30,090	$ 26,349	$ 75,730	$ 70,069
Collaboration revenue
Revenue:
Revenue	$ 1,755	$ 4,255	$ 5,324	$ 18,568