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  <xs:element id="nstg_BorrowingsUnderTermLoanAgreements" abstract="false" name="BorrowingsUnderTermLoanAgreements" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_SecuredRevolvingLoanFacilityMember" abstract="true" name="SecuredRevolvingLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_EuropeAndMiddleEastMember" abstract="true" name="EuropeAndMiddleEastMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_RepaymentOfAccruedInterestOfLongTermDebt" abstract="false" name="RepaymentOfAccruedInterestOfLongTermDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_ConvertibleDebtTermsAxis" abstract="true" name="ConvertibleDebtTermsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="nstg_TermLoanAgreementMember" abstract="true" name="TermLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_OperatingLeaseRightOfUseAssetsAmortization" abstract="false" name="OperatingLeaseRightOfUseAssetsAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsFairValue" abstract="false" name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_DebtSecuritiesandEquitySecuritiesUnrealizedGains" abstract="false" name="DebtSecuritiesandEquitySecuritiesUnrealizedGains" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_SignificantAccountingPoliciesLineItems" abstract="true" name="SignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nstg_ContractWithCustomerLiabilityIncreaseFromCashReceipts" abstract="false" name="ContractWithCustomerLiabilityIncreaseFromCashReceipts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_Debtsecuritiesandequitysecuritiesamortizedcost" abstract="false" name="Debtsecuritiesandequitysecuritiesamortizedcost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_ProductAndServiceMember" abstract="true" name="ProductAndServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_SellingStockholderMember" abstract="true" name="SellingStockholderMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_ConvertibleDebtTriggeringEvent1Member" abstract="true" name="ConvertibleDebtTriggeringEvent1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_NumberOfSalesForces" abstract="false" name="NumberOfSalesForces" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="nstg_CRGServicingLLCAmendedAndRestatedLoanAgreementMember" abstract="true" name="CRGServicingLLCAmendedAndRestatedLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_SaleOfStockGrossConsiderationReceivedOnTransaction" abstract="false" name="SaleOfStockGrossConsiderationReceivedOnTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_DebtSecuritiesAndEquitySecuritiesFairValue" abstract="false" name="DebtSecuritiesAndEquitySecuritiesFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_ProductConsumablesMember" abstract="true" name="ProductConsumablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_ContractWithCustomerLiabilityIncreaseDecreaseInCustomerDeposits" abstract="false" name="ContractWithCustomerLiabilityIncreaseDecreaseInCustomerDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_StatementofChangesinStockholdersEquityAbstract" abstract="true" name="StatementofChangesinStockholdersEquityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nstg_CollaborationMember" abstract="true" name="CollaborationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_ConvertibleDebtTriggeringEvent2Member" abstract="true" name="ConvertibleDebtTriggeringEvent2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_LamResearchCorporationMember" abstract="true" name="LamResearchCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_ContractWithCustomerLiabilityCustomerDepositsCurrent" abstract="false" name="ContractWithCustomerLiabilityCustomerDepositsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nstg_ProductInstrumentsMember" abstract="true" name="ProductInstrumentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="nstg_WarrantsIssuedwithDebt" abstract="false" name="WarrantsIssuedwithDebt" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="nstg_MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" abstract="false" name="MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="nstg_SignificantAccountingPoliciesTable" abstract="true" name="SignificantAccountingPoliciesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="nstg_DeferredPaymentObligationAccruedInterestRate" abstract="false" name="DeferredPaymentObligationAccruedInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="nstg_ClassOfWarrantOrRightNumberOfWarrantsOrRightsExercised" abstract="false" name="ClassOfWarrantOrRightNumberOfWarrantsOrRightsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="nstg_DebtIssuanceCostEquityComponentNet" abstract="false" name="DebtIssuanceCostEquityComponentNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
