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  <xsd:element id="nstg_ContractWithCustomerLiabilityIncreaseDecreaseInCustomerDeposits" name="ContractWithCustomerLiabilityIncreaseDecreaseInCustomerDeposits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_ContractWithCustomerLiabilityIncreaseFromCashReceipts" name="ContractWithCustomerLiabilityIncreaseFromCashReceipts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="nstg_ConversionOfAccruedInterestToLongTermDebt" name="ConversionOfAccruedInterestToLongTermDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ConvertibleDebtTermsAxis" name="ConvertibleDebtTermsAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ConvertibleDebtTermsDomain" name="ConvertibleDebtTermsDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ConvertibleDebtTriggeringEvent1Member" name="ConvertibleDebtTriggeringEvent1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ConvertibleDebtTriggeringEvent2Member" name="ConvertibleDebtTriggeringEvent2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ConvertibleSeniorNotesDue2025Member" name="ConvertibleSeniorNotesDue2025Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_CorporateEquitySecuritiesMember" name="CorporateEquitySecuritiesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_DebtIssuanceCostEquityComponentNet" name="DebtIssuanceCostEquityComponentNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_DebtIssuanceCostLiabilityComponentNet" name="DebtIssuanceCostLiabilityComponentNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_DebtSecuritiesAndEquitySecuritiesFairValue" name="DebtSecuritiesAndEquitySecuritiesFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_DebtSecuritiesAndEquitySecuritiesUnrealizedLosses" name="DebtSecuritiesAndEquitySecuritiesUnrealizedLosses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_DebtSecuritiesandEquitySecuritiesUnrealizedGains" name="DebtSecuritiesandEquitySecuritiesUnrealizedGains" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="nstg_Debtsecuritiesandequitysecuritiesamortizedcost" name="Debtsecuritiesandequitysecuritiesamortizedcost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_DeferredPaymentObligationAccruedInterestRate" name="DeferredPaymentObligationAccruedInterestRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="nstg_DeferredRentCreditAndLiabilitiesOtherThanLongtermDebtNoncurrent" name="DeferredRentCreditAndLiabilitiesOtherThanLongtermDebtNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="nstg_EuropeAndMiddleEastMember" name="EuropeAndMiddleEastMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_ExtinguishmentOfDebtTerminationFee" name="ExtinguishmentOfDebtTerminationFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="nstg_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_InterestAccruedOnLongTermNotes" name="InterestAccruedOnLongTermNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_LamResearchCorporationMember" name="LamResearchCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" name="MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_NumberOfPlatforms" name="NumberOfPlatforms" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_NumberOfSalesForces" name="NumberOfSalesForces" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_OperatingLeaseRightOfUseAssetsAmortization" name="OperatingLeaseRightOfUseAssetsAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_OutstandingPrincipalOfConvertibleDebt" name="OutstandingPrincipalOfConvertibleDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="nstg_ProductAndServiceMember" name="ProductAndServiceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ProductConsumablesMember" name="ProductConsumablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ProductInstrumentsMember" name="ProductInstrumentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_PublicStockOfferingMember" name="PublicStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_RepaymentOfAccruedInterestOfLongTermDebt" name="RepaymentOfAccruedInterestOfLongTermDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="nstg_SaleOfStockGrossConsiderationReceivedOnTransaction" name="SaleOfStockGrossConsiderationReceivedOnTransaction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SecuredRevolvingLoanFacilityMember" name="SecuredRevolvingLoanFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SellingStockholderMember" name="SellingStockholderMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SignificantAccountingPoliciesLineItems" name="SignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SignificantAccountingPoliciesTable" name="SignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_StatementofChangesinStockholdersEquityAbstract" name="StatementofChangesinStockholdersEquityAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_TermLoanAgreementMember" name="TermLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_TotalProductsAndServicesMember" name="TotalProductsAndServicesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_UpfrontFeeOfAggregatePrincipalAmountPercentage" name="UpfrontFeeOfAggregatePrincipalAmountPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="nstg_WarrantsIssuedwithDebt" name="WarrantsIssuedwithDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
</xsd:schema>
