Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenue:
Revenue	$ 26,605	$ 27,688
Costs and expenses:
Cost of product and service revenue	11,017	8,709
Research and development	17,502	16,027
Selling, general and administrative	25,721	23,436
Total costs and expenses	54,240	48,172
Loss from operations	(27,635)	(20,484)
Other income (expense):
Interest income	704	523
Interest expense	(2,883)	(1,748)
Other expense, net	(1,607)	(110)
Loss on extinguishment of debt and termination of revolving loan facility	(7,143)	0
Total other expense, net	(10,929)	(1,335)
Net loss before provision for income tax	(38,564)	(21,819)
Provision for income tax	(60)	(79)
Net loss	$ (38,624)	$ (21,898)
Net loss per share - basic and diluted (in dollars per share)	$ (1.04)	$ (0.69)
Weighted average shares used in computing basic and diluted net loss per share (in shares)	36,999	31,569
Total product and service revenue
Revenue:
Revenue	$ 24,496	$ 21,350
Collaboration revenue
Revenue:
Revenue	$ 2,109	$ 6,338