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  <xsd:element abstract="true" id="nstg_ExercisePriceRangeSevenMember" name="ExercisePriceRangeSevenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ExercisePriceRangeSixMember" name="ExercisePriceRangeSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ExercisePriceRangeTenMember" name="ExercisePriceRangeTenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_ExtendedProductWarrantyPeriod" name="ExtendedProductWarrantyPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_FairValueOfWarrantsIssuedWithLongTermDebt" name="FairValueOfWarrantsIssuedWithLongTermDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_FederalAndStateMember" name="FederalAndStateMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_GainLossonDispositionofBusinessNetofTransactionCosts" name="GainLossonDispositionofBusinessNetofTransactionCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="nstg_IncomeTaxReconciliationChangeInTaxCredits" name="IncomeTaxReconciliationChangeInTaxCredits" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_IncomeTaxesAndTaxRelatedLineItems" name="IncomeTaxesAndTaxRelatedLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_IncomeTaxesAndTaxRelatedTable" name="IncomeTaxesAndTaxRelatedTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_IncreaseDecreaseInDeferredRentAndOtherOperatingLiabilities" name="IncreaseDecreaseInDeferredRentAndOtherOperatingLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_InterestAccruedOnLongTermNotes" name="InterestAccruedOnLongTermNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_InventoryExchangedForServices" name="InventoryExchangedForServices" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_InventoryTransferredToPropertyAndEquipmentForInternalUse" name="InventoryTransferredToPropertyAndEquipmentForInternalUse" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_InventoryValuationReservesAdditions" name="InventoryValuationReservesAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_LamResearchCorporationMember" name="LamResearchCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_LeaseAndLoanerInstrumentsMember" name="LeaseAndLoanerInstrumentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_LicenseAndSaleOfIntellectualPropertyForCommonStock" name="LicenseAndSaleOfIntellectualPropertyForCommonStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_LineCreditFacilityAdditionalBorrowingCapacity" name="LineCreditFacilityAdditionalBorrowingCapacity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="nstg_ManufacturingEquipmentMember" name="ManufacturingEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" name="MaximumAmountOfRoyaltiesPayableRatioToLicenseAndServiceRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:pureItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_MedivationInc.andAstellasPharmaInc.Member" name="MedivationInc.andAstellasPharmaInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_MerckSharpAndDohmeCorporationMember" name="MerckSharpAndDohmeCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_MinimumLiquidityCovenantAmount" name="MinimumLiquidityCovenantAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_Nstg_ReimbursementOfCounterpartyCosts" name="Nstg_ReimbursementOfCounterpartyCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_NumberOfOperatingLeases" name="NumberOfOperatingLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_NumberOfPlatforms" name="NumberOfPlatforms" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_OperatingLeaseRightOfUseAssetsAmortization" name="OperatingLeaseRightOfUseAssetsAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_PremiumonExercisePriceofAdditionalWarrantsDebt" name="PremiumonExercisePriceofAdditionalWarrantsDebt" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="nstg_ProductAndServiceMember" name="ProductAndServiceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ProductConsumablesMember" name="ProductConsumablesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ProductInVitroDiagnosticKitsMember" name="ProductInVitroDiagnosticKitsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_ProductInstrumentsMember" name="ProductInstrumentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_ProductWarrantyAccrualPeriod" name="ProductWarrantyAccrualPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_PrototypeSystemsMember" name="PrototypeSystemsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_PrototypesAndOtherEquipmentMember" name="PrototypesAndOtherEquipmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_PublicStockOfferingMember" name="PublicStockOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_ReimbursementOfCounterpartyCostsMaximumNumberOfEmployees" name="ReimbursementOfCounterpartyCostsMaximumNumberOfEmployees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_RentalInstrumentsReclassifiedFromInventory" name="RentalInstrumentsReclassifiedFromInventory" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_RepaymentOfAccruedInterestOfLongTermDebt" name="RepaymentOfAccruedInterestOfLongTermDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="nstg_SaleOfStockGrossConsiderationReceivedOnTransaction" name="SaleOfStockGrossConsiderationReceivedOnTransaction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="nstg_ScheduleOfDeferredTaxAssetsValuationAllowanceTableTextBlock" name="ScheduleOfDeferredTaxAssetsValuationAllowanceTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_ScheduleOfEffectsOfTemporaryDifferencesThatGiveRiseToDeferredTaxAssetsAndLiabilitiesTableTextBlock" name="ScheduleOfEffectsOfTemporaryDifferencesThatGiveRiseToDeferredTaxAssetsAndLiabilitiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SecuredRevolvingLoanFacilityMember" name="SecuredRevolvingLoanFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SellingStockholderMember" name="SellingStockholderMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SignificantAccountingPoliciesLineItems" name="SignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_SignificantAccountingPoliciesTable" name="SignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_StandardProductWarrantyPeriod" name="StandardProductWarrantyPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_TermLoanAgreementMember" name="TermLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_TotalProductsAndServicesMember" name="TotalProductsAndServicesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="nstg_TwoThousandFourStockOptionPlanAndTwoThousandThirteenEquityIncentiveStockPlanMember" name="TwoThousandFourStockOptionPlanAndTwoThousandThirteenEquityIncentiveStockPlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_UnrecognizedTaxBenefitsIncreaseDecreasesResultingFromCurrentPeriodTaxPositions" name="UnrecognizedTaxBenefitsIncreaseDecreasesResultingFromCurrentPeriodTaxPositions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="nstg_UpfrontDebtFeePercentage" name="UpfrontDebtFeePercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="nstg_VeracyteInc.Member" name="VeracyteInc.Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="nstg_WarrantsIssuedwithDebt" name="WarrantsIssuedwithDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
</xsd:schema>
