Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenue:
Product and service	$ 15,765	$ 12,136
Collaboration	2,298	2,561
Total revenue	18,063	14,697
Costs and expenses:
Cost of product and service revenue	7,163	5,870
Research and development	10,801	7,208
Selling, general and administrative	17,565	14,904
Total costs and expenses	35,529	27,982
Loss from operations	(17,466)	(13,285)
Other income (expense):
Interest income	147	68
Interest expense	(1,501)	(1,315)
Other income (expense), net	13	(71)
Total other income (expense), net	(1,341)	(1,318)
Net loss before provision for income tax	(18,807)	(14,603)
Provision for income tax	(45)	0
Net loss	$ (18,852)	$ (14,603)
Net loss per share - basic and diluted (in dollars per share)	$ (0.87)	$ (0.74)
Weighted average shares used in computing basic and diluted net loss per share (in shares)	21,588	19,669