Investments, Debt and Equity Securities [Abstract] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Table] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] Major Types of Debt and Equity Securities [Domain] Corporate debt securities Corporate Debt Securities [Member] U.S. government-related debt securities US Government Agencies Debt Securities [Member] Schedule of Available-for-sale Securities [Line Items] Schedule of Available-for-sale Securities [Line Items] Amortized cost Available-for-sale Securities, Amortized Cost Basis Gross unrealized gains Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Gross unrealized losses Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Fair value Available-for-sale Securities, Current Debt Disclosure [Abstract] Remainder of 2016 Long-term Debt, Maturities, Repayments of Principal, Remainder of Fiscal Year 2017 Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months 2018 Long-term Debt, Maturities, Repayments of Principal in Year Two 2019 Long-term Debt, Maturities, Repayments of Principal in Year Three 2020 Long-term Debt, Maturities, Repayments of Principal in Year Five Thereafter Long-term Debt, Maturities, Repayments of Principal after Year Five Total long-term debt and lease financing obligations Long-term Debt Risks and Uncertainties [Abstract] Concentration Risk [Table] Concentration Risk [Table] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Customer Concentration Risk Customer Concentration Risk [Member] Credit Concentration Risk Credit Concentration Risk [Member] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Total revenue Sales Revenue, Net [Member] Total accounts receivable Accounts Receivable [Member] Concentration Risk [Line Items] Concentration Risk [Line Items] Number of customer that individually represented more than 10% of total revenue and accounts receivable Number Of Customers Meeting Concentration Risk Threshold Represents the number of major customers who meet the identified concentration risk threshold of 10%. Concentration risk percentage Concentration Risk, Percentage Investments that were other-than-temporarily impaired Other than Temporary Impairment Losses, Investments, Available-for-sale Securities Income Statement [Abstract] Revenue: Revenues [Abstract] Product and service Revenue, Net Collaboration Recognition of Deferred Revenue Total revenue Revenues Costs and expenses: Costs and Expenses [Abstract] Cost of product and service revenue Cost of Revenue Research and development Research and Development Expense Selling, general and administrative Selling, General and Administrative Expense Total costs and expenses Costs and Expenses Loss from operations Operating Income (Loss) Other income (expense): Other Income and Expenses [Abstract] Interest income Investment Income, Interest Interest expense Investment Income, Investment Expense Other income (expense), net Other Nonoperating Income (Expense) Total other income (expense), net Nonoperating Income (Expense) Net loss before provision for income tax Income (Loss) from Continuing Operations before Income Taxes, Extraordinary Items, Noncontrolling Interest Provision for income tax Income Tax Expense (Benefit) Net loss Net Income (Loss) Attributable to Parent Net loss per share - basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Weighted average shares used in computing basic and diluted net loss per share (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Components of Borrowings, Including Current Portion Schedule of Debt [Table Text Block] Scheduled Future Principal Payments under Outstanding Debt Obligations Schedule of Maturities of Long-term Debt [Table Text Block] Maturing in one year or less Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value Maturing in one to three years Available For Sale Securities Debt Maturities After One Through Three Years Fair Value Available for sale securities debt maturities after one through three years fair value. Total available-for-sale securities Available-for-sale Securities, Debt Securities Line of Credit Facility [Table] Line of Credit Facility [Table] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Term Loan Agreement Term Loan Agreement [Member] Term Loan Agreement [Member] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Maximum Maximum [Member] Scenario [Axis] Scenario [Axis] Scenario, Unspecified [Domain] Scenario, Unspecified [Domain] Forecast Scenario, Forecast [Member] Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Credit facility, additional borrowing capacity Line Credit Facility Additional Borrowing Capacity Line Credit Facility Additional Borrowing Capacity Percentage of accrue interest Long-term Debt, Percentage Bearing Fixed Interest, Percentage Rate Percentage of deferred payment Deferred Payment Obligation Accrued Interest Rate Payment-in-kind percentage as agreed upon in the financing agreement to defer interest payments. Interest deferral period Debt Instrument, Interest Deferral Period Debt Instrument, Interest Deferral Period Deferred interest payment Debt, Deferred Interest Payment Debt, Deferred Interest Payment Term loans payable Loans Payable Interest payment period Debt Instrument, Interest Payment Period Debt Instrument, Interest Payment Period Number of installments Debt Instrument, Number Of Installments During Eighth Year Of Term Debt Instrument, Number of Installments During Eighth Year of Term Percentage of redemption fee Debt Instrument, Redemption Price, Percentage Annual percentage decrease Debt Instrument, Redemption Price, Annual Percentage Decrease Debt Instrument, Redemption Price, Annual Percentage Decrease Percentage payment up on repayment of principal amount Line of Credit Facility, Commitment Fee Percentage Long term liability Long-term Line of Credit, Noncurrent Minimum liquidity Minimum Liquidity Covenant Amount Minimum Liquidity Covenant Amount Annual revenue requirements Revenue Recognition, Milestone Method, Revenue Recognized Increase in annual revenue in fiscal years Increased Annual Revenues Increased Annual Revenues Segment Reporting [Abstract] Schedule of Revenues from External Customers and Long-Lived Assets [Table] Schedule of Revenues from External Customers and Long-Lived Assets [Table] Geographical [Axis] Geographical [Axis] Geographical [Domain] Geographical [Domain] United States UNITED STATES Revenues from External Customers and Long-Lived Assets [Line Items] Revenues from External Customers and Long-Lived Assets [Line Items] Number of sales forces Number Of Sales Forces Number of Sales Forces Number of reportable segment Number of Reportable Segments Total revenue Long-term Debt and Lease Financing Obligations Debt Disclosure [Text Block] Inventory Disclosure [Abstract] Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Subsequent Events [Abstract] Subsequent Event [Table] Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock [Domain] Sale of Stock [Domain] At the market equity offering At The Market Equity Offering [Member] At The Market Equity Offering [Member] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Cowen and Company, LLC Cowen And Company Llc [Member] Cowen And Company Llc [Member] Subsequent Event [Line Items] Subsequent Event [Line Items] Common stock, shares issued (in shares) Stock Issued During Period, Shares, New Issues Proceeds from equity offering program Proceeds from Issuance of Common Stock Proceeds from underwritten public offering after fees and commissions Sale of Stock, Consideration Received on Transaction Common stock remained available for sale Common Stock Value Available For Issuance Common stock value available for issuance. Accounting Policies [Abstract] Description of Business Business Description and Basis of Presentation [Text Block] Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Revenue Recognition Revenue Recognition, Policy [Policy Text Block] Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Earnings Per Share [Abstract] Summary of Shares Underlying Outstanding Options and Warrants were Excluded from Computation of Basic and Diluted Net Loss Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Document And Entity Information [Abstract] Document And Entity Information. Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Classification of Revenue by Geography Revenue from External Customers by Geographic Areas [Table Text Block] Statement of Cash Flows [Abstract] Operating activities Net Cash Provided by (Used in) Continuing Operations [Abstract] Net loss Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Stock-based compensation expense Allocated Share-based Compensation Expense Amortization of premium on short-term investments Investment Income, Net, Amortization of Discount and Premium Interest accrued on long-term debt Interest Accrued On Long Term Notes Interest expense incurred, not yet paid, on all other long-term debt, which may include (1) interest on long-term notes, and (2) amortization of issuance costs not otherwise separately disclosed. Conversion of accrued interest to long-term debt Conversion Of Accrued Interest To Long Term Debt Conversion Of Accrued Interest To Long Term Debt (Gain) loss on sale of property and equipment Gain (Loss) on Disposition of Property Plant Equipment Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Accounts receivable, net Increase (Decrease) in Accounts Receivable Inventory Increase (Decrease) in Inventories Prepaid expenses and other Increase (Decrease) in Prepaid Expense and Other Assets Other assets Increase (Decrease) in Other Operating Assets Accounts payable Increase (Decrease) in Accounts Payable Accrued liabilities Increase (Decrease) in Accrued Liabilities Deferred revenue Increase (Decrease) in Deferred Revenue Deferred rent Straight Line Rent Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Operating Activities Investing activities Net Cash Provided by (Used in) Investing Activities [Abstract] Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Proceeds from sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Proceeds from sale of short-term investments Proceeds from Sale of Short-term Investments Proceeds from maturity of short-term investments Proceeds from Maturities, Prepayments and Calls of Available-for-sale Securities Purchases of short-term investments Payments to Acquire Available-for-sale Securities Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Investing Activities Financing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Borrowings under long-term debt agreement Proceeds from (Repayments of) Other Long-term Debt Repayment of lease financing obligations Repayment Of Capital Lease Obligation Repayment Of Capital Lease Obligation Proceeds from sale of common stock, net Deferred offering costs Payment of Financing and Stock Issuance Costs Proceeds from issuance of common stock for employee stock purchase plan Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Excluding Stock Options Proceeds from exercise of stock options Proceeds from Stock Options Exercised Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net decrease in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect Effect of exchange rate changes on cash and cash equivalents Effect of Exchange Rate on Cash and Cash Equivalents Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value [Abstract] Beginning of period Cash and Cash Equivalents, at Carrying Value End of period Information about Geographic Areas Segment Reporting Disclosure [Text Block] Company's Available-for-Sale Securities by Level within Fair Value Hierarchy Fair Value, by Balance Sheet Grouping [Table Text Block] Significant Accounting Policies [Table] Significant Accounting Policies [Table] A summary of information pertaining to the Basis of Presentation and Summary of Significant Accounting Policies disclosure as a whole for which no other established gaap taxonomy identified hypercube is available. Minimum Minimum [Member] Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Extended line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Extended warranty period Extended Product Warranty Period The extended product warranty liability period. Does not include increases or decreases in the standard warranty liability. Standard warranty period Standard Product Warranty Period The standard product warranty liability period. Does not include increases or decreases in an extended warranty liability. Percentage used to determine discount for stand-alone sales (previous 12 months) Percentage Used To Determine Discount For Standalone Sales, Within Previous 12 Months Represents the method (vendor-specific objective evidence, third-party eveidence, estiamted selling price) used to establish the selling price of the significant unit of accounting for allocation of the consideration of the multiple-deliverable arrangement. Deferred Revenue Disclosure [Abstract] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Collaborative Arrangement Collaborative Arrangement [Member] New Clinical Collaborative Arrangement [Member] New Clinical Collaborative Arrangement [Member] New Clinical Collaborative Arrangement [Member] Clinical Research Collaborative Arrangement Clinical Collaborative Arrangement [Member] Clinical Collaborative Arrangement [Member] Development Funding Development Funding [Member] Development Funding [Member] Celgene Corporation Celgene Corporation [Member] Celgene Corporation [Member] Merck Sharp & Dohme Corp. Merck Sharp And Dohme Corporation [Member] Merck Sharp And Dohme Corporation [Member] Medivation, Inc. and Astellas Pharma, Inc. Medivation, Inc. and Astellas Pharma, Inc. [Member] Medivation, Inc. and Astellas Pharma, Inc. [Member] Deferred Revenue Arrangement Type [Axis] Deferred Revenue Arrangement Type [Axis] Deferred Revenue [Domain] Deferred Revenue [Domain] Upfront Payment Arrangement Up-front Payment Arrangement [Member] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Maximum success-based milestone payments Collaboration agreement upfront payment Deferred Revenue, Additions Minimum annual revenue period Revenue Recognition, Milestone Method, Minimum Annual Revenue Period Revenue Recognition, Milestone Method, Minimum Annual Revenue Period Amount of certain milestones achieved in account receivable Accounts Receivable, Net, Current Revenue recognized under collaboration agreement Deferred revenue recorded under collaboration agreement Deferred Revenue Estimated deferred revenue recognized within one year Deferred Revenue, Current Collaborative agreement period Collaborative Agreement Period Of Contract Collaborative Agreement Period Of Contract Short-Term Investments Available-for-Sale Securities Available-for-sale Securities [Table Text Block] Fair Values of Available-for-Sale Securities by Contractual Maturity Investments Classified by Contractual Maturity Date [Table Text Block] Statement of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Short-term investments Accounts receivable, net Inventory Inventory, Net Prepaid expenses and other Prepaid Expense and Other Assets, Current Total current assets Assets, Current Restricted cash Restricted Cash and Cash Equivalents, Noncurrent Deferred offering costs Deferred Offering Costs Property and equipment, net Property, Plant and Equipment, Net Other assets Other Assets, Noncurrent Total assets Assets Liabilities and Stockholders’ Equity (Deficit) Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued liabilities Accrued Liabilities, Current Deferred revenue, current portion Deferred rent, current portion Deferred Rent Credit, Current Lease financing obligations, current portion Capital Lease Obligations, Current Total current liabilities Liabilities, Current Deferred revenue, net of current portion Deferred Revenue, Noncurrent Deferred rent and other long-term liabilities Deferred Rent Credit And Liabilities, Other Than Long-term Debt, Noncurrent Deferred Rent Credit And Liabilities, Other Than Long-term Debt, Noncurrent Long-term debt and lease financing obligations, net of current portion and debt issuance costs Long-term Debt and Capital Lease Obligations Total liabilities Liabilities Commitment and contingencies Commitments and Contingencies Stockholders’ equity (deficit): Stockholders' Equity Attributable to Parent [Abstract] Preferred stock, $0.0001 par value, 15,000 shares authorized; none issued Preferred Stock, Value, Issued Common stock, $0.0001 par value, 150,000 shares authorized; 19,928 and 19,570 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital, Common Stock Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated deficit Retained Earnings (Accumulated Deficit) Total stockholders’ equity (deficit) Stockholders' Equity Attributable to Parent Total liabilities and stockholders’ equity (deficit) Liabilities and Equity Net Loss Per Share Earnings Per Share [Text Block] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Options to purchase common stock Employee Stock Option [Member] Restricted stock units Restricted Stock Units (RSUs) [Member] Common stock warrants Warrant [Member] Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock Common Stock [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Anti-dilutive securities excluded from computation of earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Raw materials Inventory, Raw Materials, Net of Reserves Work in process Inventory, Work in Process, Net of Reserves Finished goods Inventory, Finished Goods, Net of Reserves Inventory, net Basis of Presentation and Summary of Significant Accounting Policies Basis of Presentation and Significant Accounting Policies [Text Block] Concentration of Risks Concentration Risk Disclosure [Text Block] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value, Hierarchy [Axis] Fair Value, Hierarchy [Axis] Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Level 1 Fair Value, Inputs, Level 1 [Member] Level 2 Fair Value, Inputs, Level 2 [Member] Level 3 Fair Value, Inputs, Level 3 [Member] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Money market fund Money Market Funds [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Total Assets, Fair Value Disclosure Americas Americas [Member] Europe & Middle East EMEA [Member] Asia Pacific Asia Pacific [Member] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common stock, shares authorized (in shares) Common Stock, Shares Authorized Common stock, shares issued (in shares) Common Stock, Shares, Issued Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument [Line Items] Debt Instrument [Line Items] Lease financing obligations Capital Lease Obligations Unamortized debt issuance costs Unamortized Debt Issuance Expense Current portion of lease financing obligations Long-term Debt, Current Maturities Long-term debt and lease financing obligations, net of debt issuance costs and current portion Statement of Comprehensive Income [Abstract] Change in unrealized gain or loss on short-term investments Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Short-term Investments Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] Subsequent Event Subsequent Events [Text Block] Inventory Inventory Disclosure [Text Block]