Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued Liabilities Accounts Payable, Current Accounts payable Accounts Receivable [Member] Total accounts receivable [Member] Accounts Receivable, Net, Current Accounts receivable, net Amount of certain milestones achieved in account receivable Accretion Of Preferred Stock Accretion Of Preferred Stock Accretion of preferred stock Accrued Clinical Expense Current Accrued Clinical Expense Current Clinical study costs Accrued Liabilities, Current Accrued liabilities Total accrued liabilities Accrued Offering Costs Accrued Offering Costs Accrual of offering costs Accrued Professional Fees, Current Accounting and legal Accrued Royalties, Current Royalties payable Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Accumulated depreciation Less: Accumulated depreciation and amortization Accumulated Other Comprehensive Income (Loss), Net of Tax Other comprehensive loss AOCI Attributable to Parent [Member] Other Comprehensive Loss [Member] Additional Paid in Capital, Common Stock Additional paid-in-capital Additional Paid-in Capital [Member] Additional Paid-in Capital [Member] Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature Conversion of warrants from warrants for preferred stock to warrants for common stock Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Initial public offering, issuance cost Advertising Expense Advertising costs Allocated Share-based Compensation Expense Stock-based compensation Total share-based compensation expense Allowance for Doubtful Accounts Receivable, Current Allowance for doubtful accounts Allowance for Doubtful Accounts Receivable, Period Increase (Decrease) Allowance for doubtful accounts, additions Allowance for Doubtful Accounts Receivable, Write-offs Write-offs of uncollectible accounts Amended Collaborative Agreement [Member] Amended Collaborative Agreement [Member] Amended Collaborative Agreement [Member] Amendment Flag Amendment Flag Americas [Member] Americas [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Anti-dilutive securities excluded from computation of earnings per share Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Area of Real Estate Property General office, laboratory, and research and development space leased Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Asia Pacific [Member] Asia Pacific [Member] Asset-backed Securities [Member] Asset-backed securities [Member] Assets Total assets Assets [Abstract] Assets Assets, Current Total current assets Assets, Current [Abstract] Current assets: Assets, Fair Value Disclosure Total At The Market Equity Offering [Member] At The Market Equity Offering [Member] At the market equity offering [Member] Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax Gross unrealized gains Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax Gross unrealized losses Available-for-sale Securities, Amortized Cost Basis Amortized cost Available-for-sale Securities, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss 12 Months or Greater, Gross unrealized losses Available-for-sale Securities, Continuous Unrealized Loss Position, Accumulated Loss Total, Gross unrealized losses Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value Total, Fair value Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value [Table Text Block] Summary of Investments in Continuous Unrealized Loss Position Available-for-sale Securities, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Less Than 12 Months, Gross unrealized losses Available-for-sale Securities, Continuous Unrealized Loss Position, Less than Twelve Months, Fair Value Less Than 12 Months, Fair value Available-for-sale Securities, Continuous Unrealized Loss Position, Twelve Months or Longer, Fair Value 12 Months or Greater, Fair value Available-for-sale Securities, Current Fair value Short-term investments Available for sale securities debt maturities after one through three years fair value. Available For Sale Securities Debt Maturities After One Through Three Years Fair Value Maturing in one to three years Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value Maturing in one year or less Available-for-sale Securities, Debt Securities Total available-for-sale securities Available-for-sale Securities [Table Text Block] Short-Term Investments Available-for-Sale Securities Award Type [Axis] Award Type [Axis] Bank trust deposits current. Bank Trust Deposits Current Subsidiary bank trust deposits Basis of Accounting, Policy [Policy Text Block] Accounting Principles and Principles of Consolidation Business Description and Basis of Presentation [Text Block] Description of the Business Capital Lease Obligations Lease financing obligations Capital Lease Obligations, Current Lease financing obligations, current portion Current portion of lease financing obligations Capital Lease Obligations [Member] Leased Property [Member] Cash and Cash Equivalents, at Carrying Value End of year Beginning of year Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value [Abstract] Cash and cash equivalents: Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents, Fair Value Disclosure Cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Net increase (decrease) in cash and cash equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Celgene Corporation [Member] Celgene Corporation [Member] Celgene Corporation [Member] Class of Stock [Domain] Class of Stock [Domain] Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price of warrants Class of Warrant or Right, Number of Securities Called by Warrants or Rights Number of shares issuable upon exercise of warrants Collaborative arrangement development milestone payment. Collaborative Arrangement Development Milestone Payment Development payments Collaborative Arrangement Disclosure [Text Block] Collaboration Agreements Collaborative Arrangement [Member] Collaborative Arrangement [Member] Collaborative Arrangement Milestone Payment Collaborative Arrangement Milestone Payment Collaboration arrangements, revenue Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Commitments and Contingencies Commitments and contingencies (Note 15) Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Common And Preferred Stock [Line Items] Common And Preferred Stock [Line Items] Common And Preferred Stock [Line Items] Common And Preferred Stock [Table] Common And Preferred Stock [Table] Common And Preferred Stock [Table] Common Stock, Capital Shares Reserved for Future Issuance Common stock reserved for issuance Common Stock [Member] Common Stock [Member] Common Stock, Par or Stated Value Per Share Common stock price per share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Balances at end of period, shares Balances at beginning of period, shares Common stock, shares outstanding Common Stock, Value, Issued Common stock, $0.0001 par value, 150,000 shares authorized; 19,570 and 18,272 shares issued and outstanding at December 31, 2015 and 2014, respectively Common stock value available for issuance. Common Stock Value Available For Issuance Common stock remained available for sale Common stock votes per share one. Common Stock Votes Per Share 1 Each share of common stock is entitled to vote Compensation and Retirement Disclosure [Abstract] Compensation and Retirement Disclosure [Abstract] Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Computer Equipment [Member] Computer Equipment [Member] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risks Concentration Risk, Percentage Concentration risk, percentage Concentration Risk Type [Domain] Concentration Risk Type [Domain] Construction in Progress Expenditures Incurred but Not yet Paid Accrual of construction costs for leasehold improvements Construction in Progress [Member] Construction in Progress [Member] Construction Payable, Current Construction related costs for leasehold improvements Contractual Obligation Total Contractual Obligation, Due after Fifth Year Thereafter Contractual Obligation, Due in Fifth Year 2020 Contractual Obligation, Due in Fourth Year 2019 Contractual Obligation, Due in Next Fiscal Year 2016 Contractual Obligation, Due in Second Year 2017 Contractual Obligation, Due in Third Year 2018 Conversion Of Accrued Interest To Long Term Debt Conversion Of Accrued Interest To Long Term Debt Conversion of accrued interest to long-term debt Conversion Of Preferred Stock Warrants To Common Stock Warrants Shares Conversion Of Preferred Stock Warrants To Common Stock Warrants Shares Preferred stock warrants were converted into warrants to purchase common stock Conversion of Stock, Amount Converted Conversion of convertible preferred stock to common stock Convertible Preferred Stock Subject to Mandatory Redemption [Member] Mandatorily Redeemable Convertible Preferred Stock [Member] Corporate Debt Securities [Member] Corporate debt securities [Member] Cost of Revenue Cost of product and service revenue Cost Of Revenue [Member] Cost Of Revenue [Member] Cost of Revenue [Member] Cost of Sales, Policy [Policy Text Block] Cost of Revenue Costs and Expenses Total costs and expenses Costs and Expenses [Abstract] Costs and expenses: Counterparty Name [Axis] Counterparty Name [Axis] Cowen And Company Llc [Member] Cowen And Company Llc [Member] Cowen And Company, LLC [Member] Credit Concentration Risk [Member] Credit Concentration Risk [Member] Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Current Federal, State and Local, Tax Expense (Benefit) [Abstract] Current: Current Federal Tax Expense (Benefit) Domestic Current Fiscal Year End Date Current Fiscal Year End Date Current Foreign Tax Expense (Benefit) Foreign Current Income Tax Expense (Benefit) Total current provision Customer Concentration Risk [Member] Customer Concentration Risk [Member] Debt and Capital Lease Obligations Total long-term debt and lease financing obligations Debt Conversion, Converted Instrument, Expiration or Due Date, Year Warrant expiration date Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Long-Term Debt Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Frequency of Periodic Payment Principal and interest payment frequency Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Instrument, Redemption Price, Percentage Percentage of redemption fee Deferred Charges, Policy [Policy Text Block] Deferred Offering Costs Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] Deferred Federal Income Tax Expense (Benefit) Domestic Deferred Foreign Income Tax Expense (Benefit) Foreign Deferred Income Tax Expense (Benefit) Total deferred provision Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] Deferred: Deferred Offering Costs Deferred offering costs Deferred Payment Obligation Accrued Interest Deferred Payment Obligation Accrued Interest Deferred interest Payment-in-kind percentage as agreed upon in the financing agreement to defer interest payments. Deferred Payment Obligation Accrued Interest Rate Percentage of deferred payment Deferred Rent Credit, Current Deferred rent, current portion Deferred Rent Credit, Noncurrent Deferred rent liability Deferred rent, net of current portion Deferred Revenue Collaboration agreement upfront payment Deferred revenue recorded under collaboration agreement Deferred Revenue, Additions Collaboration agreement upfront payment Deferred Revenue Arrangement Type [Axis] Deferred Revenue Arrangement Type [Axis] Deferred Revenue [Domain] Deferred Revenue [Domain] Deferred Revenue, Current Deferred revenue, current portion Estimated deferred revenue recognized within one year Deferred Revenue Disclosure [Abstract] Deferred Revenue Disclosure [Abstract] Deferred Revenue, Noncurrent Deferred revenue, net of current portion Deferred Tax Assets, Gross Total deferred tax assets Deferred Tax Assets, Net of Valuation Allowance Net deferred tax assets Deferred Tax Assets, Operating Loss Carryforwards Net operating loss carryforwards Deferred Tax Assets, Other Other Deferred Tax Assets, Tax Credit Carryforwards, Research Research and development tax credit carryforwards Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Stock-based compensation Deferred Tax Assets, Valuation Allowance Balance at End of Year Balance at Beginning of Year Less: Valuation allowance Defined Contribution Plan, Cost Recognized Contribution for retirement plan Deposits Assets, Current Deposits for inventory Depreciation, Depletion and Amortization Depreciation and amortization Development Funding [Member] Development Funding [Member] Development Funding [Member] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-based Compensation Document And Entity Information. Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Period End Date Document Period End Date Document Type Document Type Earliest Tax Year [Member] Earliest Tax Year [Member] Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Net loss per share-basic and diluted Earnings Per Share, Policy [Policy Text Block] Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Statutory federal income tax rate Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations Effect of exchange rate changes on cash and cash equivalents EMEA [Member] Europe & Middle East [Member] Employee-related Liabilities, Current Employee compensation Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Unrecognized compensation cost, weighted-average recognized period Employee Service Share-based Compensation, Tax Benefit from Compensation Expense Tax benefit recognized related to share-based compensation cost Employee Stock Option [Member] Options to purchase common stock [Member] Employee Stock Purchase Plan Contribution Percentage Employee Stock Purchase Plan Contribution Percentage Contribution percentage of purchase shares on participants eligible compensation Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan Offering Period Employee Stock Purchase Plan Offering Period Length of offering period, in months Employee Stock Purchase Plan Offering Period Description Employee Stock Purchase Plan Offering Period Description Offering period description Employee Stock Purchase Plan Purchase Period Employee Stock Purchase Plan Purchase Period Length of purchase periods, in months Entity Central Index Key Entity Central Index Key