Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenue:
Product revenue, net	$ 26,185
License revenue	1,500
Total revenue	27,685
Operating costs and expenses:
Cost of sales	5,572
Selling, general and administrative	106,693	$ 53,798	$ 31,808
Research and development	207,810	222,798	208,472
Total operating expense	320,075	276,596	240,280
Loss from operations	(292,390)	(276,596)	(240,280)
Other (expenses) income:
Interest income	1,256	958	971
Interest expense	(720)
Other (expenses) income	(101)	(373)	25
Total other (expenses) income	435	585	996
Net loss	(291,955)	(276,011)	(239,284)
Net loss applicable to common stock	$ (291,955)	$ (276,011)	$ (239,284)
Net loss per common share—basic and diluted	$ (7.85)	$ (8.29)	$ (7.45)
Weighted-average common shares outstanding—basic and diluted	37,169,678	33,295,114	32,126,094