Stockholders Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands														1 Months Ended			12 Months Ended
	Dec. 15, 2016	Oct. 20, 2016	Oct. 19, 2016	Dec. 15, 2015	Jan. 27, 2015	Jan. 21, 2015	Dec. 15, 2014	Feb. 14, 2014	Feb. 12, 2014	Feb. 10, 2014	Oct. 24, 2012	Oct. 19, 2012	Oct. 18, 2012	Oct. 31, 2016	Jan. 31, 2014	Oct. 31, 2011	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Oct. 04, 2011
Stockholders Equity Note [Line Items]
Common stock, par value																	$ 0.0001	$ 0.0001
Issuance of common stock, per share																	$ 40.00	$ 190.00	$ 122.50
Net proceeds from issuance of common stock																	$ 161,854	$ 205,133	$ 129,440
Underwriters option exercisable period			30 days
Issuance of common stock on exercise of option																	43,751	757,038	430,490
Common stock, shares authorized																	100,000,000	100,000,000
Shares of stock authorized before amendment																	110,000,000
Preferred stock, shares authorized																	10,000,000
Preferred stock, par value																	$ 0.0001
Equity method investment ownership percentage																					100.00%
Common stock, shares outstanding																	36,826,010	32,466,842
Warrant expiration date																	Oct. 04, 2021
Issuance of common stock on exercise of option																	6,578,522	5,542,285	3,978,126	2,604,224
Weighted-average grant date fair value of options granted																	$ 25.69	$ 68.30	$ 101.17
2011 Plan
Stockholders Equity Note [Line Items]
Common stock shares reserved for issuance																	10,529,412
Issuance of common stock on exercise of option																	7,209,131
Common stock are available for future issuance																	1,741,857
Performance Awards
Stockholders Equity Note [Line Items]
Number of shares granted to employees																	0
Shares vesting period																	3 years
Shares issued to the employees	0			11,495			11,495
Shares cancelled	9,469			7,447			7,447										9,469
Weighted-average grant date fair value of restricted stock units																	$ 102.46
Performance Awards | Employees
Stockholders Equity Note [Line Items]
Common stock price															$ 102.46
Shares vesting period															3 years
Non Vested Stock Options
Stockholders Equity Note [Line Items]
Estimated unrecognized employee compensation cost related to non-vested stock options granted																	$ 132,100
Estimated unrecognized employee compensation cost related to non-vested stock options granted, Weighted-average period of recognition																	1 year 8 months 12 days
Restricted Stock Units
Stockholders Equity Note [Line Items]
Number of shares granted to employees																	640,644
Shares cancelled																	7,219
Estimated unrecognized employee compensation cost related to non-vested stock options granted																	$ 29,700
Estimated unrecognized employee compensation cost related to non-vested stock options granted, Weighted-average period of recognition																	2 years 7 months 6 days
Weighted-average grant date fair value of restricted stock units																	$ 54.35
President
Stockholders Equity Note [Line Items]
Percentage of shares held by related party																21.00%
Common Stock
Stockholders Equity Note [Line Items]
Issuance of common stock (in shares)																	4,312,500	1,150,000	1,126,530
Issuance of common stock on exercise of option																	46,668	757,038	430,490
Common stock, shares outstanding																	36,826,010	32,466,842	30,548,309	28,991,289
Shares of common stock that could be acquired by warrant																	2,116,250
Common stock price																	$ 16
Common Stock | President
Stockholders Equity Note [Line Items]
Common stock, shares outstanding																18,666,733
Maximum | 2011 Plan
Stockholders Equity Note [Line Items]
Stock options granted, term																	10 years
Maximum | Performance Awards
Stockholders Equity Note [Line Items]
Number of shares granted to employees																			28,411
Maximum | Performance Awards | Employees
Stockholders Equity Note [Line Items]
Number of shares granted to employees															28,411
Minimum | Performance Awards | Employees
Stockholders Equity Note [Line Items]
Common stock price															$ 47.53
Minimum | Common Stock | President
Stockholders Equity Note [Line Items]
Minimum ownership percentage of outstanding shares of common stock the president need to maintain after issuance of warrants																20.00%
Underwritten Public Offering
Stockholders Equity Note [Line Items]
Issuance of common stock (in shares)			3,750,000			1,000,000				979,592			7,500,000
Common stock, par value			$ 0.0001			$ 0.0001				$ 0.0001			$ 0.0001
Issuance of common stock, per share			$ 40.00			$ 190.00				$ 122.50			$ 16.00
Net proceeds from issuance of common stock		$ 161,900			$ 205,100			$ 129,400			$ 129,200			$ 161,900
Gross proceeds from issuance of common stock					218,500			138,000			138,000
Public offering, underwriting discount and estimated offering expenses					$ 13,400			$ 8,600			$ 8,800
Overallotment Option Exercise by Underwriters
Stockholders Equity Note [Line Items]
Issuance of common stock (in shares)						150,000			146,938			1,125,000
Overallotment Option Exercise by Underwriters | Maximum
Stockholders Equity Note [Line Items]
Issuance of common stock (in shares)			562,500