X0609 4 2026-06-11 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001716328 Stuglik Brian M false C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 1700 LOS ANGELES CA 90024 1 1 Common Stock 2026-06-11 4 A 0 27000 0 A 121958 D Common Stock 2026-06-12 4 S 0 8100 7.19890 D 113858 D Represents Restricted Stock Units which vest in full on the earlier of the one-year anniversary of the date of grant and the date of the annual shareholder meeting following the date of grant, subject to the Reporting Person's continued service with the Issuer. Adoption date of referenced 10b5-1(c) plan is: 03-12-2025 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $6.98 to $7.32, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. /s/ Gordon Esplin as attorney-in-fact for Brian M. Stuglik 2026-06-15