X0508 4 2025-02-07 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001807133 Ludwig Jeffrey Jerome C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 1 Chief Commercial Officer 0 Common Stock 2025-02-07 4 A 0 47841 0 A 156792 D Stock Option (Right to Buy) 2.78 2025-02-07 4 A 0 66221 0 A 2035-02-06 Common Stock 66221 66221 D Represents Restricted Stock Units ("RSUs") that shall vest with respect to one-fourth (1/4th) of the RSUs on each of July 1, 2025, January 1, 2026, July 1, 2026 and January 1, 2027, subject to the Grantee's continued service with the Company through the applicable vesting date. Options shall vest and become exercisable with respect to one-fourth (1/4th) of the shares subject thereto on each of July 1, 2025, January 1, 2026, July 1, 2026 and January 1, 2027, subject to the Optionee's continued service with the Company through the applicable vesting date. /s/ Gordon Esplin as attorney-in-fact for Jeffrey Jerome Ludwig 2025-02-11