X0407 4 2023-07-03 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001758507 NOUGUES MAXIMO F C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 1 Chief Financial Officer 1 Common Stock 2023-07-03 4 S 0 14680 3.3112 D 144348 D Adoption date of referenced 10b5-1(c) sell to cover program is: 12-14-2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.24 to $3.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote. /s/ Gordon Esplin as attorney-in-fact for Maximo F. Nougues 2023-07-06