Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating activities:
Net income (loss)	$ 2,000	$ (29,126,000)	$ (59,995,000)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization	8,920,000	10,598,000	10,033,000
Acquired in-process research and development	7,000,000	0	0
Stock-based compensation	11,826,000	32,633,000	36,575,000
Provision for credit loss (recovery)	0	1,000,000	1,000,000
Provision for credit loss (recovery)	0	(1,000,000)	(1,000,000)
Disposal of property and equipment	1,000	1,000	0
Loss on debt extinguishment	0	8,146,000	0
Changes in operating assets and liabilities:
Accounts receivable, net	(7,824,000)	(5,983,000)	2,353,000
Inventory, net	2,583,000	(3,655,000)	(284,000)
Prepaid expenses and other	2,367,000	2,669,000	2,207,000
Other current assets	(1,982,000)	3,194,000	(3,120,000)
Accounts payable	(4,734,000)	(902,000)	(7,107,000)
Accrued expenses and other	(33,065,000)	5,209,000	19,251,000
Post-marketing commitment liability	(921,000)	(1,134,000)	(140,000)
Net cash provided by (used in) operating activities	(15,827,000)	20,650,000	773,000
Investing activities:
Purchase of property and equipment	0	0	(46,000)
Acquired in-process research and development	(7,000,000)	0	0
Purchase of available-for-sale securities	(4,836,000)	(38,073,000)	(29,826,000)
Maturity of available-for-sale securities	18,940,000	27,192,000	73,275,000
Purchase of intangible assets	0	0	(10,000,000)
Net cash provided by (used in) investing activities	7,104,000	(10,881,000)	33,403,000
Financing activities:
Net proceeds from shares issued under employee stock plans	0	0	68,000
Gross proceeds from private investments in public equity	12,500,000	0	0
Issuance costs associated with private investments in public equity	(277,000)	0	0
Proceeds from debt	0	98,500,000	8,444,000
Payment of debt	0	(100,000,000)	(8,444,000)
Payment of prepayment costs, end of loan payment and other extinguishment costs	0	(8,521,000)	0
Payment of debt issuance costs	0	(1,910,000)
Installment payment for purchase of intangible asset	0	(20,000,000)	(10,000,000)
Net cash provided by (used in) financing activities	12,223,000	(31,931,000)	(9,932,000)
Net increase (decrease) in cash, cash equivalents and restricted cash	3,500,000	(22,162,000)	24,244,000
Cash, cash equivalents and restricted cash, beginning of period	75,292,000	97,454,000	73,210,000
Cash, cash equivalents and restricted cash, end of period	78,792,000	75,292,000	97,454,000
Supplemental disclosures of non-cash investing and financing activities:
Intangibles in accrued in-license rights	12,500,000	0	20,000,000
Supplemental disclosure of cash flow information:
Interest paid	10,319,000	10,342,000	9,703,000
Income taxes paid	$ 384,000	$ 324,000	$ 207,000