Note 2 - Significant Accounting Policies (Details Textual) $ in Thousands	1 Months Ended	12 Months Ended
	Sep. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Payments to Acquire Intangible Assets		$ (0)	$ (0)	$ 10,000
Sublease Agreement, Potential Milestone Payments		579,800
Restricted Cash, Total		2,600	12,200
Cash and Cash Equivalents, and Restricted Cash In Excess of Insured Limits		78,500
Accounts Receivable, Credit Loss Expense (Reversal)		$ 0	(1,000)	1,000
Average Incremental Borrowing Rate		10.90%
Operating Lease, Impairment Loss		$ 0	0	0
Research and Development in Process		7,000	0	0
Potential Milestone Payments		102,500
Amortization of Intangible Assets		8,000	8,000	$ 6,300
Finite-Lived Intangible Asset, Expected Amortization, Year One		9,739
Finite-Lived Intangible Asset, Expected Amortization, Year Two		9,739
Finite-Lived Intangible Asset, Expected Amortization, Year Three		9,739
Finite-Lived Intangible Asset, Expected Amortization, Year Four		9,739
Finite-Lived Intangible Asset, Expected Amortization, Year Five		9,739
Finite-Lived Intangible Asset, Expected Amortization, Year Six		9,700
Finite-Lived Intangible Asset, Expected Amortization, Year Seven		9,700
Finite-Lived Intangible Asset, Expected Amortization, Year Eight		2,400
Payroll Tax Credit		3,800
Pfizer License Agreement [Member]
Potential Milestone Payments		12,500
NERLYNX [Member]
Revenue from Contract with Customer, Including Assessed Tax		$ 250,000
Takeda License Agreement [Member]
Research and Development in Process	$ 7,000
Selling, General and Administrative Expenses [Member]
Operating Lease, Impairment Loss					$ 1,200
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)		3 years
Telephone Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)		3 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)		7 years
Customer Concentration Risk [Member] | Customers With More than 10% Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total		$ 28,900	$ 23,200
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Number of Major Customers		2	2	2
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Customer 1 [Member]
Concentration Risk, Percentage		35.00%	31.00%	33.00%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Customer 2 [Member]
Concentration Risk, Percentage		20.00%	22.00%	21.00%
Revision of Prior Period, Adjustment [Member]
Payments to Acquire Intangible Assets			$ 10,000