X0306 4 2023-02-10 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001727172 HUNT DOUGLAS M C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 1 See Remarks Common Stock 2023-02-10 4 A 0 48136 0 A 119486 D Stock Option (Right to Buy) 4.39 2023-02-10 4 A 0 66864 0 A 2033-02-09 Common Stock 66864 66864 D Represents Restricted Stock Units ("RSUs") that shall vest with respect to one-fourth (1/4th) of the RSUs on each of July 1, 2023, January 1, 2024, July 1, 2024 and January 1, 2025, subject to the Grantee's continued service with the Company through the applicable vesting date. Options shall vest and become exercisable with respect to one-fourth (1/4th) of the shares subject thereto on each of July 1, 2023, January 1, 2024, July 1, 2024 and January 1, 2025, subject to the Optionee's continued service with the Company through the applicable vesting date. The Reporting Person is the Senior Vice President of Regulatory Affairs of the Issuer. /s/ Gordon Esplin as attorney-in-fact for Douglas M. Hunt 2023-02-14