X0306 4 2023-02-10 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001358285 AUERBACH ALAN H C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 1 1 1 President and CEO Common Stock 2023-02-10 4 A 0 186403 0 A 7039041 D Stock Option (Right to Buy) 4.39 2023-02-10 4 A 0 258924 0 A 2033-02-09 Common Stock 258924 258924 D Subject to Grantee's continued status as an Employee of the Company, the Restricted Stock Units ("RSUs") shall vest with respect to one-fourth (1/4th) of the RSUs on each of July 1, 2023, January 1, 2024, July 1, 2024 and January 1, 2025, subject to acceleration in certain events. Subject to Optionee's continued status as an Employee of the Company, Options shall vest and become exercisable with respect to one-fourth (1/4th) of the Shares (as defined in the Plan) subject thereto on each of July 1, 2023, January 1, 2024, July 1, 2024 and January 1, 2025, subject to acceleration in certain events. /s/ Alan H. Auerbach 2023-02-14