X0306 4 2022-07-29 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001827015 Cesano Alessandra C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 2150 LOS ANGELES CA 90024 1 STOCK OPTION (RIGHT TO BUY) 2.93 2022-07-29 4 A 0 100000 0 A 2032-07-28 COMMON STOCK 100000 100000 D The vesting commencement date of the option is July 29, 2022 (the "Option Vesting Commencement Date"). Subject to the Reporting Person's continued service with the Issuer through the applicable vesting date, the option vests (i) on the first anniversary of the Option Vesting Commencement Date with respect to one-third (1/3rd) of the shares subject thereto and (ii) on each monthly anniversary of the Option Vesting Commencement Date thereafter with respect to an additional 1/36th of the shares subject thereto. /s/ Gordon Esplin, Attorney-in-Fact for Alessandra Cesano 2022-08-02