X0306 4 2022-06-16 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001589597 WILSON TROY EDWARD C/O PUMA BIOTECHNOLGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 1 Common Stock 2022-06-16 4 S 0 27858 2.5835 D 27350 D Common Stock 400 I By Child #1 Common Stock 150 I By Child #2 These shares were sold pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.544 to $2.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Troy Edward Wilson 2022-06-21