Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Operating activities:
Net loss	$ (29,126)	$ (59,995)	$ (75,595)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	10,598	10,033	8,077
Stock-based compensation	32,633	36,575	57,327
Provision for credit loss recovery	(1,000)
Provision for credit loss expense	0	1,000	0
Disposal of property and equipment	1	0	54
Loss on impairment of asset	0	0	1,183
Loss on debt extinguishment	8,146	0	8,047
Changes in operating assets and liabilities:
Accounts receivable, net	(5,983)	2,353	(8,123)
Inventory, net	(3,655)	(284)	(545)
Prepaid expenses and other	2,669	2,207	414
Other current assets	3,194	(3,120)	1,464
Accounts payable	(902)	(7,107)	(1,526)
Accrued expenses and other	5,209	19,251	22,599
Post-marketing commitment liability	(1,134)	(140)	9,000
Net cash provided by operating activities	20,650	773	22,376
Investing activities:
Purchase of property and equipment	0	(46)	(306)
Purchase of available-for-sale securities	(38,073)	(29,826)	(127,198)
Sale of available-for-sale securities	0	0	28,135
Maturity of available-for-sale securities	27,192	73,275	104,532
Purchase of intangible assets	0	(10,000)	0
Net cash provided by (used in) investing activities	(10,881)	33,403	5,163
Financing activities:
Net proceeds from shares issued under employee stock plans	0	68	1,351
Proceeds from debt	98,500	8,444	25,000
Payment of debt	(100,000)	(8,444)	(80,000)
Payment of prepayment costs, end of loan payment and other extinguishment costs	(8,521)	0	(7,793)
Payment of debt issuance costs	(1,910)	0	(5,625)
Installment payment for purchase of intangible asset	(20,000)	(10,000)	0
Net cash used in financing activities	(31,931)	(9,932)	(67,067)
Net increase (decrease) in cash, cash equivalents and restricted cash	(22,162)	24,244	(39,528)
Cash, cash equivalents and restricted cash, beginning of period	97,454	73,210	112,738
Cash, cash equivalents and restricted cash, end of period	75,292	97,454	73,210
Supplemental disclosures of non-cash investing and financing activities:
Intangibles in accrued expenses	0	20,000	0
Property and equipment purchases in accounts payable	0	0	25
Supplemental disclosure of cash flow information:
Interest paid	10,342	9,703	11,739
Income taxes paid	$ 324	$ 207	$ 53