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Note 14 - Commitments and Contingencies (Details Textual)
$ / shares in Units, $ in Millions
1 Months Ended 12 Months Ended
Nov. 02, 2021
USD ($)
Oct. 29, 2021
USD ($)
Jun. 23, 2021
USD ($)
Mar. 02, 2020
USD ($)
Mar. 15, 2019
USD ($)
Jan. 29, 2019
$ / shares
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Oct. 09, 2020
USD ($)
Milestone Payments Maximum Amount             $ 187.5    
Potential Milestone Payments               $ 90.0  
Percentage of Unpaid Portion of Milestone Payments Interest Rate               6.25%  
Milestone Payment             $ 1.8    
Hsu v. Puma Biotechnology, Inc., [Member]                  
Loss Contingency, Estimate of Possible Loss               $ 54.2  
Loss Contingency, Damages Awarded Per Share (in dollars per share) | $ / shares           $ 4.50      
Loss Contingency, Damages Awarded Percent of Total Claim           5.00%      
Loss Contingency, Claimed Damages Awarded Per Share (in dollars per share) | $ / shares           $ 87.20      
Loss Contingency, Claimed Damages, Amount                 $ 50.5
Litigation Settlement, Amount Awarded to Other Party $ 54.2 $ 54.2              
Legal Settlements Payments, Number of Installments 2                
Eshelman v. Puma Biotechnology, Inc. [Member]                  
Loss Contingency, Estimate of Possible Loss               2.9  
Litigation Settlement, Amount Awarded to Other Party       $ 26.3          
Litigation Settlement, Expense       $ 3.0          
Loss Contingency Accrual, Period Increase (Decrease), Total     $ (22.4)            
Letters of Credit Outstanding, Amount               8.9  
Eshelman v. Puma Biotechnology, Inc. [Member] | Compensatory Damages [Member]                  
Loss Contingency, Damages Awarded, Value         $ 15.9        
Eshelman v. Puma Biotechnology, Inc. [Member] | Punitive Damages [Member]                  
Loss Contingency, Damages Awarded, Value         $ 6.5        
Clinical Trial Contracts [Member]                  
Potential Milestone Payments               17.3  
Contractual Obligation, Total               $ 54.8  
Minimum [Member] | Clinical Trial Contracts [Member]                  
Termination Notice Period (Day)               30 days  
Maximum [Member] | Eshelman v. Puma Biotechnology, Inc. [Member]                  
Loss Contingency, Damages Sought, Value               $ 2.9  
Maximum [Member] | Clinical Trial Contracts [Member]                  
Termination Notice Period (Day)               45 days